tDCS for Treatment Resistant Obsessive Compulsive Disorder

  • End date
    Mar 12, 2022
  • participants needed
  • sponsor
    Centre Hospitalier Henri Laborit
Updated on 12 March 2021
transcranial direct current stimulation


It's a multicentric, randomized, controlled study concerning 100 patients with treatment-resistant obsessive compulsive disorders (OCD). The aim of this study is to evaluate the effect of transcranial direct current stimulation (tDCS) on OCD patients.

Condition Obsessive-Compulsive Disorder, ANXIETY NEUROSIS, Anxiety Disorders (Pediatric), Generalized Anxiety Disorder (GAD), Generalized Anxiety Disorder (GAD - Pediatric), Anxiety Disorders, obsessive compulsive disorder
Treatment sham stimulation, Active stimulation
Clinical Study IdentifierNCT03304600
SponsorCentre Hospitalier Henri Laborit
Last Modified on12 March 2021


Yes No Not Sure

Inclusion Criteria

Meets criteria for obsessive compulsive disorder according to Diagnostic and Statistical Manual (DSM IV) with a "good insight" (BABS)
No current depressive and suicidal risks
No epileptic pathology
Age: Participants will be both males and females, 18-70 years of age included
Chronic Obsessive compulsive disorder ( Total Y-BOCS>20 or Y-BOCS one subscale > 15)
Obsessive compulsive disorder resistant to pharmacology treatment
at least 2 antidepressants (IRS type) (> 12 weeks)
cognitive and comportment therapy since at least one year
Treatment stability (antidepressants) for more than 12 weeks without significant improvement
Affiliation to a social security system (recipient or assignee)
Signed written inform consent form

Exclusion Criteria

Female subject who is pregnant, or of child-bearing age, sexually active and not using reliable contraception or who is nursing
Patient under curators
Patient hospitalized under duress
Meets another diagnosis of axe 1 of DSM-IV
Current depressive or suicidal risks
Patient with any form of metal in the cranium, a pacemaker, skull defects, or skin lesions to the scalp (cuts, abrasions, rash)
Epileptic patient
Patient with a medical history of cranial trauma
Patient unable to give his or hers informed consent
Clear my responses

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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