Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy For Locally Advanced Breast Cancer

  • End date
    Aug 24, 2022
  • participants needed
  • sponsor
    Memorial Sloan Kettering Cancer Center
Updated on 24 January 2021
advanced breast cancer
locally advanced breast cancer
axillary lymph node dissection
sentinel node
sentinel lymph node biopsy


This study is being done to help the investigators determine how accurate the sentinel lymph node biopsy (SLNB) procedure is in identifying residual cancer cells after neoadjuvant chemotherapy in patients presenting with locally advanced breast cancer.

Condition Breast Cancer, Locally Advanced Breast Cancer, Breast Cancer Diagnosis, breast carcinoma, cancer, breast
Treatment Sentinel Lymph Node Biopsy (SLNB)
Clinical Study IdentifierNCT03255577
SponsorMemorial Sloan Kettering Cancer Center
Last Modified on24 January 2021


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Inclusion Criteria

Is your age greater than or equal to 18 yrs?
Are you female?
Do you have any of these conditions: Locally Advanced Breast Cancer or Breast Cancer?
Do you have any of these conditions: Locally Advanced Breast Cancer or breast carcinoma or cancer, breast or Breast Cancer or Breast Cancer Diagnosis?
Female patients over 18 years of age with biopsy-proven breast cancer
Patients presenting with locally advanced disease in the breast (cT4) and/or in the nodes (cN2/N3) as assessed by clinical exam and imaging
Patients presenting to surgery clinic after receipt of NAC at outside hospital with documentation of cT4 or cN2/3 disease on initial outside physical exam and imaging studies
Patients receiving NAC and having a nodal complete clinical response as assessed by physical exam

Exclusion Criteria

Patients with a prior history of ipsilateral breast cancer
Pregnant patients
Patients with persistent palpable axillary nodes after NAC, as assessed by physical exam
Patients not consenting to ALND
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