In Vivo Assessment of Glutamine Utilization by Bone Marrow Plasma Cells

  • STATUS
    Recruiting
  • End date
    Jan 1, 2024
  • participants needed
    20
  • sponsor
    Mayo Clinic
Updated on 24 March 2022
Accepts healthy volunteers

Summary

This pilot study will first establish the feasibility of an in vivo methodology of assessing the utilization of glutamine into the TCA cycle of normal bone marrow plasma cells from healthy subjects while comparing it to an ex vivo approach

Description

Twenty healthy adult study participants between the ages of 18 and 60 years will be recruited to participate in this pilot study that will include two groups: a) Ex Vivo group (10 volunteers) and b) In Vivo group (10 volunteers). Volunteers will be recruited to either group in a sequential alternating fashion.

In vivo 13C SIRM studies evaluating the utilization of glutamine into the TCA cycle of normal bone marrow plasma cells.

Details
Condition Healthy
Treatment bone marrow aspiration, 5-13C-Glutamine
Clinical Study IdentifierNCT03384108
SponsorMayo Clinic
Last Modified on24 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Ages 18-60
Able to provide written consent

Exclusion Criteria

Renal Failure
Pregnancy
Active steroid use
Active liver Disease
Anemia (Hemoglobin < 12.5 g/dL in men and < 11.5 g/dL in women)
H/O alcohol use (average > 2 drinks per day)
BMI > 30
Clear my responses

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Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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