This Study Tests the Effect of Certain Medicines on the Transport of Other Medicines in the Body of Healthy Men

  • STATUS
    Not Recruiting
  • participants needed
    47
  • sponsor
    Boehringer Ingelheim
Updated on 22 January 2021

Summary

The primary objective of this trial is to investigate the relative bioavailabilities of digoxin, furosemide, metformin and rosuvastatin given as a cocktail alone and as a cocktail together with the following drug transporter inhibitors:

Part 1: verapamil (P-gp) and rifampin (OATP1B1/1B3) Part 2: cimetidine (OCT2/MATE) Part 3: probenecid (OAT1/3) The secondary objective is to investigate other potential changes in pharmacokinetics (e.g. in clearance, volume of distribution, etc.) of digoxin, furosemide, metformin and rosuvastatin given as a cocktail alone and as a cocktail together with the inhibitors describe above.

Details
Condition healthy
Treatment Metformin, Verapamil, Rosuvastatin, rifampin, Furosemide, Digoxin, Cimetidine, Cimetidine, Probenecid, Probenecid
Clinical Study IdentifierNCT03307252
SponsorBoehringer Ingelheim
Last Modified on22 January 2021

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