Last updated on September 2018

Evaluation of Xiaflex: Trial of Effectivenss iN Dupuytren's

Brief description of study

This is a prospective, multi-centre, pragmatic randomized controlled trial to compare both the clinical effectiveness and cost-effectiveness of collagenase injections (CI) versus limited palmar fasciectomy (LPF) to determine if collagenase is a superior treatment in terms of improved quality of life and reducing recurrence of the disease without serious complications. Since collagenase injections are costly it is also important to know if this novel intervention is cost-effective from the patient, Ministry of Health and societal perspectives.

Clinical Study Identifier: NCT02725528

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Bing Gan, MD

St. Joseph's Healthcare
London, ON Canada
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James Bain, MD

Hamilton Health Sciences
Hamilton, ON Canada
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Achilleas Thoma, MD MSc FRCSC

St. Joseph's Healthcare / McMaster University
Hamilton, ON Canada
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Carolyn Levis, MD

St. Joseph's Hospital
Hamilton, ON Canada
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Rodger Shortt, MD

Oakville Trafalgar Hospital
Oakville, ON Canada
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Nancy de Kleer, MD

Halton Healthcare Services
Oakville, ON Canada
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Yasser El-Sheikh, MD

North York General Hospital
Toronto, ON Canada
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Bimpe Ayeni, MD

679 Davis St. Suite 209
Newmarket, ON Canada
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Tara Lynn Teshima, MD

Markham Stouffville Hospital
Markham, ON Canada
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Murray Allen

The Ottawa Hospital
Ottawa, ON Canada
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