Last updated on April 2020

Mifepristone and Misoprostol Versus Misoprostol Alone in the Medical Management of Missed Miscarriage


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Missed abortion
  • Age: Between 16 - 100 Years
  • Gender: Female

Inclusion Criteria:

  • Women diagnosed with missed miscarriage by pelvic ultrasound scan in the first 13+6 weeks of pregnancy that choose to have medical management of miscarriage.
  • Age 16 years and over
  • Willing and able to give informed consent.

Exclusion Criteria:

  • Women opting for alternative methods of miscarriage management (expectant or surgical)
  • Diagnosis of incomplete miscarriage.
  • Life threatening bleeding.
  • Contraindications to mifepristone or misoprostol use for example chronic adrenal failure, known hypersensitivity to either drug, haemorrhagic disorders and anticoagulant therapy, prosthetic heart valve or history of endocarditis, existing cardiovascular disease, severe asthma uncontrolled by therapy or inherited porphyria.
  • Participation in any other blinded, placebo-controlled trials of investigational medicinal products in pregnancy.
  • Previous participation in the MifeMiso trial
  • Woman not able to attend for day 6-7 ultrasound scan

Recruitment Status: Closed


Brief Description Eligibility Contact Research Team


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