Study to Assess Efficacy and Safety of Cx601 Adult Allogeneic Expanded Adipose-derived Stem Cells (eASC) for the Treatment of Complex Perianal Fistula(s) in Participants With Crohn's Disease (CD)

  • STATUS
    Recruiting
  • End date
    Sep 30, 2022
  • participants needed
    554
  • sponsor
    Tigenix S.A.U.
Updated on 5 August 2020
Investigator
Takeda Study Registration Call Center
Primary Contact
MedStar Georgetown University Hospital (3.3 mi away) Contact
+146 other location
luminal
corticosteroids
remission
methotrexate
monoclonal antibodies
adalimumab
ustekinumab
immunosuppressive agents
infliximab
abdominal pain
mercaptopurine
vedolizumab
azathioprine
tumour necrosis
certolizumab pegol

Summary

The purpose of this study is to evaluate the combined remission of complex perianal fistulas, defined as the clinical assessment at Week 24 of closure of all treated external openings that were draining at baseline despite gentle finger compression, and absence of collections greater than (>) 2 centimeter (cm) (in at least 2 dimensions) confirmed by blinded central magnetic resonance imaging (MRI) assessment at Week 24.

Description

This study is to assess the efficacy and safety of Cx601, eASC, for the treatment of complex perianal fistulas in participants with Crohn's disease.

The study will randomize approximately 554 participants.

  • Cx601 eASCs intralesional injection
  • Placebo - Cx601 placebo-matching eASCs intralesional injection

Study treatments will be allocated, on a 1:1 ratio, by central randomization through interactive web response system (IWRS). The study will follow an add-on design, participants receiving any ongoing concomitant medical treatment, at stable doses at the time of screening, for the CD will be allowed to continue it throughout the study.

The primary efficacy analysis, will be conducted at Week 24 timepoint. The double blind design will be maintained up to Week 52 (both participant and investigator) by a specific blinding for study treatment administration and for evaluating its efficacy.

This multicenter trial will be conducted globally across 150 centers. The overall time to participate in this study is approximately 5 years.

Details
Treatment Placebo, Cx601
Clinical Study IdentifierNCT03279081
SponsorTigenix S.A.U.
Last Modified on5 August 2020

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Eligibility

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Inclusion Criteria

Is your age greater than or equal to 18 yrs?
Gender: Male or Female
Do you have any of these conditions: Crohn's Disease (Pediatric) or Inflammatory bowel disease or Crohn's Disease?
Signed informed consent
Participants of either gender greater than or equal to (>=) 18 years and less than or equal to (<=) 75 years of age
Participants with CD diagnosed at least 6 months prior to Screening visit in accordance with accepted clinical, endoscopic, histological and/or radiological criteria
Presence of complex perianal fistula(s) with a maximum of 2 internal openings and a maximum of 3 external openings based on clinical assessment; a central reading of a locally performed contrast enhanced (gadolinium) pelvic MRI will be performed to confirm location of the fistula and potential associated perianal abscess(es). Fistula(s) must have been draining for at least 6 weeks prior to Screening visit. Actively draining simple subcutaneous fistula(s), at the time of Screening visit, are not allowed in this study. A complex perianal fistula is defined as a fistula that meets one or more of the following criteria
High inter-sphincteric, high trans-sphincteric, extra-sphincteric or suprasphincteric
Presence of >=2 external openings
Associated perianal abscess(es). Note: Abscesses that are larger than 2 cm at least 2 dimensions on MRI must be confirmed to have been drained adequately by the surgeon during the preparation curettage in order to be eligible
Clinically controlled, nonactive or mildly active CD, during the last six months prior to Screening visit with
A patient reported outcomes (PRO-2) score <14 at Screening, AND
A colonoscopy documenting the absence of ulcers larger than 0.5 cm in the colonic
mucosa
If colonoscopy data are not available within 6 months prior to Screening
A simple endoscopic score for Crohn's Disease (SES-CD) <=6 with absence of rectal ulcers larger than 0.5 cm must be documented in a colonoscopy performed at Screening before randomization
If colonoscopy data are available within 6 months prior to Screening, the following must be documented, otherwise a new colonoscopy (as above) will be
mandatory
The absence of ulcers larger than 0.5 cm in the colonic mucosa AND
the improvement or no worsening in abdominal pain and/or in the diarrhea, sustained for one week or more, since the last colonoscopy was performed in the clinical records until Screening visit
AND
No hemoglobin decrease >=2.0 gram per deciliter (g/dL) or an unexplained rising C-reactive protein (CRP), > 5.0 milligram per liter (mg/L) to a concentration above the referenced upper limit of normal (ULN) (unless the rise is due to a known process other than luminal Crohn's Disease), since the last colonoscopy was performed as compared to results during the Screening visit
AND
no initiation or intensification of treatment with corticosteroids, immunosuppressants or monoclonal antibodies (mAbs) dose regimen since the last endoscopy up to Screening visit. 6\. Participants whose perianal fistulas were previously treated and have shown an inadequate response or a loss of response while they were receiving either an immunosuppressive agent or tumour necrosis factor (TNF)-alpha antagonist or vedolizumab or ustekinumab, or having documented intolerance to any of these treatments administered at least at approved or recommended doses during the minimum period mentioned
Immunosuppressive agents: at least 3 months treatment with azathioprine (2-3 milligram per kilogram per day [mg/kg/day]), 6-mercaptopurine (1-1.5 mg/kg/day), or subcutaneous/intramuscular methotrexate (25 mg/week) prior to Screening for the study
TNFalpha antagonists
Infliximab: at least 14 weeks treatment at the approved doses for induction and/or maintenance in Crohns disease prior to screening for the study. For induction: 1 intravenous dose of 5 milligram per kilogram (mg/kg) followed by the same dose 2 and 6 weeks after. For maintenance: 5-10 mg/kg intravenously every 8 weeks, or more frequently
Adalimumab: at least 14 weeks treatment at the approved doses for induction and/or maintenance in Crohn's disease prior to screening for the study. For induction: 1 subcutaneous dose of 160 milligram (mg), followed by 80 mg 2 weeks after. For maintenance: 40 mg subcutaneously every other week, or weekly
Certolizumab l: at least 14 weeks treatment at the approved doses for induction and/or maintenance in Crohns disease prior to screening for the study. For induction: 1 subcutaneous dose of 400 mg, followed by the same dose 2 and 4 weeks after. For maintenance: 400 mg subcutaneously every 2 to 4 weeks
Anti-integrin: at least 14 weeks treatment of the approved dose for induction and/or maintenance in Crohns disease prior to screening for the study. For induction: Vedolizumab 300 mg. For maintenance: Vedolizumab 300 mg every 4 to 8 weeks
Anti-interleukin (IL)-12/23: at least 16 weeks treatment of the approved dose in Crohns disease prior to screening for the study. For induction: Ustekinumab, approximately 6mg/kg intravenously initially then followed by 90 mg subcutaneously every 8 weeks. 7\. Women of childbearing potential (WCBP) must have negative serum pregnancy test at screening (sensitive to 25 international units [IU] human chorionic gonadotropin [hCG]). Both WCBP or male participants participating in this study, with a WCBP as partner, must agree to use an adequate method of contraception during the entire duration of the study. An adequate method of contraception is defined as complete, non-periodic sexual abstinence (refraining from heterosexual intercourse), single-barrier method, vasectomy, adequate hormonal contraception (to have started at least 7 days prior to Screening visit), or an intra-uterine device (to have been in place for at least 2 months prior to Screening visit)

Exclusion Criteria

Concomitant rectovaginal or rectovesical fistula(s)
Participant nave to prior specific medical treatment for complex perianal fistula(s) including immunosuppressant (IS) or anti-TNFs
Presence of a perianal collection >2 cm in at least two dimensions on the central reading MRI at Screening visit that was not adequately drained as confirmed by the surgeon during the preparation procedure (week -3 to day 0)
Severe rectal and/or anal stenosis and/or severe proctitis (defined as the presence of large >0.5 cm ulcers in the rectum) that make impossible to follow the surgery procedure manual
Participant with diverting stomas
Active, uncontrolled infection requiring parenteral antibiotics
Participant with ongoing systemic or rectal steroids for CD in the last 2 weeks prior to the Preparation visit
Participants with major alteration on any of the following laboratory tests or increased risk for the surgical procedure
Serum creatinine levels >1.5 times the ULN
Total bilirubin >1.5 ULN
Aspartate Transaminase (AST)/ Alanine Transaminase (ALT) >3 times ULN
Hemoglobin <10.0 g/dL
Platelets <75.010^9/L
Albuminemia <3.0 g/dL
Suspected or documented infectious enterocolitis within two weeks prior to Screening visit
Any prior invasive malignancy diagnosed within the last 5 years prior to Screening visit. Participants with basal-cell carcinoma of the skin completely resected outside the perineal region can be included
Current or recent (within 6 months prior to the Screening visit) history of severe, progressive, and/or uncontrolled hepatic, haematological, gastrointestinal (GI) (other than CD), renal, endocrine, pulmonary, cardiac, neurological or psychiatric disease that may result in participants increased risk from study participation and/or lack of compliance with study procedures
Participants with primary sclerosing cholangitis
Participants with known chronically active hepatopathy of any origin, including cirrhosis and participants with persistent positive Hepatitis B Virus (HBV) surface antigen (HBsAg) and quantitative HBV polymerase chain reaction (PCR), or positive serology for Hepatitis C Virus (HCV) and quantitative HCV PCR within 6 months prior to Screening
Congenital or acquired immunodeficiencies, including participants known to be HIV carriers
Known allergies or hypersensitivity to penicillin or aminoglycosides; Dulbecco Modified Eagle's Medium (DMEM); bovine serum; local anaesthetics or gadolinium (MRI contrast)
Contraindication to MRI scan (example, due to the presence of pacemakers, hip replacements or severe claustrophobia)
Severe trauma within 6 months prior to Screening visit
Pregnant or breastfeeding women
Participants who do not wish to or cannot comply with study procedures
Participants currently receiving, or having received any investigational drug within 3 months prior to Screening visit
Participants previously treated with Cx601 or other allogeneic stem-cell therapy cannot be enrolled into this clinical study
Any major surgery of the GI tract (including one or more segments of the colon or terminal ileum) within 6 months prior the screening or any minor surgery of the GI tract within 3 months prior to screening
Participants who had local perianal surgery other than drainage for the fistula within 6 months prior to the Screening visit, or those who may need surgery in the perianal region for reasons other than fistulas at the time of inclusion in the study
Contraindication to the anaesthetic procedure
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