Cytokine Induced Memory-like NK Cell Adoptive Therapy for Relapsed AML After Allogeneic Hematopoietic Cell Transplant

  • End date
    Apr 23, 2026
  • participants needed
  • sponsor
    Washington University School of Medicine
Updated on 15 April 2021


Donor Lymphocyte Infusion (DLI) following salvage chemotherapy is the one of the most widely used treatment approaches in patients who relapse after allogeneic hematopoietic cell transplant (allo-HCT). However, the complete remission (CR) rates and long term survival remain very poor in these patients and, therefore, there is an unmet need to develop more effective treatment approaches in patients who relapse after allo-HCT.

Based on the initial promising results with our ongoing cytokine-induced memory-like (CIML) natural killer (NK) cell trial, the investigators hypothesize that combining the CIML NK cells with DLI approach will significantly enhance the graft versus leukemia and therefore potentially provide potentially curative therapy for these patients with otherwise extremely poor prognosis. Combining CIML NK cells with the DLI platform will also potentially allow these adoptively transferred cells to persist for longer duration as they should not be rejected by donor T cells as the CIML NK cells are derived from the same donor. The use of CIML NK cells is unlikely to lead to excessive graft versus host disease (GVHD) as previous studies have not been associated with excessive GVHD rates.

Condition Acute Myeloid Leukemia in Children
Treatment Peripheral blood draw, CIML NK Cell Infusion, CD3+ T Cell Product Infusion
Clinical Study IdentifierNCT03068819
SponsorWashington University School of Medicine
Last Modified on15 April 2021


Yes No Not Sure

Inclusion Criteria

At least 18 years of age
Same donor as used for the allo-HCT
In general good health, and medically able to tolerate leukapheresis
Ability to understand and willingness to sign an IRB approved written informed consent document

Exclusion Criteria

Active hepatitis, positive for HTLV, or HIV on donor viral screen
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