OCTA in Mild Cognitive Impairment and Alzheimer's Disease

  • STATUS
    Recruiting
  • End date
    Dec 31, 2022
  • participants needed
    1000
  • sponsor
    Duke University
Updated on 25 January 2022
cognitive impairment
optical coherence tomography
alzheimer's disease
parkinson's disease
mild cognitive impairment
neurodegenerative disorders
huntington's chorea
huntington's disease
disease or disorder
multiple sclerosis
neurodegenerative diseases
chorea
Accepts healthy volunteers

Summary

This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography angiography (OCTA) to assess the structure and function of the retinal microvasculature in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD) or other neurodegenerative disease, multiple sclerosis, and Huntington's disease.

Description

Using a multidisciplinary approach, this study aims to yield new insight into the vascular pathophysiology of mild cognitive impairment (MCI) and Alzheimer's Disease (AD) Parkinson's Disease (PD) or other neurodegenerative disease. The investigators propose to develop and evaluate biomarkers using non-invasive optical coherence tomography angiography (OCTA) to assess the structure and function of the retinal microvasculature in persons with MCI and AD, PD or other neurodegenerative disease multiple sclerosis, and Huntington's disease..

The investigators hypothesize that microvascular network alterations in the retina mirror and possibly precede changes in the cerebral microcirculation seen in these diseases. Using advanced image analysis, the investigators aim to evaluate markers of reduced capillary blood flow and non-perfusion in the superficial and deep retinal vascular plexuses and choriocapillaris imaged using OCTA, in a resolution not previously possible, that would complement already established retinal structural markers and increase their sensitivity and specificity in the early detection of MCI and AD, PD, multiple sclerosis, and Huntington's disease. or other neurodegenerative disease.

This study looks to provide a proof of concept for OCTA-based retinal microvascular biomarkers as an effective screening tool in cognitive aging.

Details
Condition Alzheimer Disease, Mild Cognitive Impairment, Retinal Vascular, Parkinson Disease, Multiple Sclerosis, Huntington Disease, Neuro-Degenerative Disease
Treatment Retinal Imaging
Clinical Study IdentifierNCT03233646
SponsorDuke University
Last Modified on25 January 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients with neurodegenerative disease (MCI/ADPD/MS/HD)
Age-gender-race-matched controls

Exclusion Criteria

History of known or suspected diagnosis of non-AD
Associated dementia
Diabetes mellitus
Inability to cooperate with or complete testing
Evidence of glaucoma
Macular degeneration
Other neurologic or age-related ocular conditions that would impact OCTA segmentation. -Eyes that have had intraocular surgery, other than cataract surgery, will be excluded
If two eyes satisfy the inclusion criteria, both eyes will be included in the study. If one eye satisfies the inclusion criteria, the eye that qualifies will be included in the study
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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