Last updated on August 2018

Proof-of-Concept Study of a Selective p38 MAPK Alpha Inhibitor Neflamapimod in Subjects With Mild Alzheimer's Disease

Brief description of study

This is a phase 2b, double-blind, placebo controlled proof-of-concept study of a an oral small molecule selective inhibitor of p38 alpha kinase, neflamapimod, administered for 24 weeks in subjects with mild Alzheimer's disease. The primary objective is to demonstrate significant improvement relative to placebo-treatment in episodic memory function, as assessed by the Hopkins Verbal Learning Test. Secondary endpoints include Clinical Dementia Rating scale (CDR), Wechsler Memory Scale (WMS), Mini-Mental-Status-Examination (MMSE) and Cerebrospinal fluid (CSF) biomarkers of AD disease activity and progression.

Detailed Study Description

Details provided elsewhere.

Clinical Study Identifier: NCT03402659

Contact Investigators or Research Sites near you

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Territa Santhakumaran, MD

Re:Cognition Health Guildford
Guildford, United Kingdom
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Recruitment Status: Open

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