The Pre-SPG4 Study

  • STATUS
    Recruiting
  • End date
    Dec 7, 2031
  • participants needed
    200
  • sponsor
    University Hospital Tuebingen
Updated on 7 October 2021

Summary

Study goals

  1. Prospective longitudinal data on progression in the natural course of SPG4 in presymptomatic mutation carriers prior to clinical disease onset and in early stages of disease
  2. Biomarkers providing objective measures of disease activity

Details
Condition Neuropathy, Hereditary spastic paraplegia, Hereditary motor and sensory neuropathy
Treatment MRI, SPRS Score and clinical signs, Cognition Testing using CANTAB, Lumbar Puncture and blood draw, Electrophysiology, Electrophysiology, Testing functional performance, Non motor symptoms
Clinical Study IdentifierNCT03206190
SponsorUniversity Hospital Tuebingen
Last Modified on7 October 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

First degree relatives (parents, offspring, and sibs) of SPG4 patients or symptomatic individuals with known SPAST mutation
Age 18 to 70 years
Written, informed consent (patient)

Exclusion Criteria

No known SPAST-mutation within the family
Manifest spastic gait (subclinical signs like increased deep tendon reflexes, positive Babinski sign are allowed)
Participation in interventional trials
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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