Last updated on August 2018

Quality of Sleep of Patients With Predominant Central Sleep Apnea Syndrome(SAS) Whose EF > 45% Treated by ASV

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Central Sleep Apnea Syndrome in Patients Whose EF is Above 45 Percent
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Patient over 18 years
  • Naive patient to treatment with positive pressure with AHIc > 15 requiring the establishment of an ASV to a central or combined SAS without any systolic HF (LVEF 45%) with predominant central SAS.
  • OR Patient with a predominant obstructive SAS ( 50% central event ) whose Continuous Positive Airway Pressure treatment (CPAP) does not allow adequate control of the central events: treated for at least 1 month CPAP with a residual central apnea hypopnea index greater than or equal to 10 events per hour (AHI global> 15, which AHIc 10) pressure to control obstructive events ( IAHo <5 ) controlled by polygraphy or polysomnography with a pressure test <10 cm H2O.
  • Before inclusion, for patients who have previously been treated with CPAP, a PSG diagnosis will be made after a period of wash-out of CPAP of a 1-week period.
  • Patient affiliated to the national social security (beneficiary or assignee ).
  • Patient being aware of the information form and signed informed consent.

Exclusion Criteria:

  • Patients with against -indication for the use of ASV :
  • History of massive epistaxis.
  • Diseases related to barotrauma particularly pneumothorax and pneumo- mediastinum.
  • Suspicions of meningeal gaps or trauma history of the prior stage of the skull base.
  • Shortness of breath or hypercapnia deemed incompatible by the doctor with the ASV treatment.
  • Patients with predominant obstructive sleep apnea (OSA) (> 85% obstructive events ).
  • Standardized central SAS by the Continuous Positive Airway Pressure
  • Patients with a diagnosis of systolic heart failure (LVEF 45 %) with a predominant central SAS ( > 50% central events ).
  • Person deprived of liberty by judicial or administrative decision, person under a legal protection measure (pregnant or lactating women, patients under guardianship)
  • Lack of signature for the information form and the informed consent form.

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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