The Effect of Per Oral Immunotherapy in Severe Milk Peanut and Egg Allergy in Adults

  • STATUS
    Recruiting
  • End date
    Dec 31, 2022
  • participants needed
    100
  • sponsor
    Helsinki University Central Hospital
Updated on 26 January 2021
allergen
serum ige
prick skin
milk allergy
egg allergy

Summary

The aim is to analyse the results of per oral immunotherapy treatment in severe milk, peanut or egg allergy in adults. This is the second part of the oral immunotherapy study in adults at Skin and Allergy Hospital. The diagnosis of food allergy is verified with positive history, skin prick tests, egg and milk allergen specific IgE (immunoglobulin E) antibodies. In addition, food allergy is verified with an open label (milk allergy) or blind (peanut and egg allergy) allergen specific challenge test. OIT (oral immunotherapy) is performed according to a detailed plan. Lung function parameters are followed before OIT and and a year after OIT.

Description

30 patients with milk allergy (at least 18 year olds), 30 patients with peanut allergy and 30 patients with egg allergy are treated with OIT. The diagnosis of food allergy is verified with positive history, skin prick test, egg and milk allergen specific IgE antibodies. In addition, food allergy is verified with an open label (milk allergy) or blind (peanut and egg allergy) allergen specific challenge test. Quality of life, anxiety and patient history data is collected by questionnaires. All the patients undergo a spirometry with a bronchodilatator test, exhaled nitric oxide test and a methacholine challenge before and a year after oral immunotherapy. All the patients undergoing oral immunotherapy are prescribed with emergency medication such as antihistamine tablets, prednisolon tablets (40mg for three days in adults), epinephrine autoinjector (300 g per dose) and salbutamol or terbutaline inhalator.

Details
Condition Food Allergy, food allergies
Treatment Oral immunotherapy
Clinical Study IdentifierNCT03361072
SponsorHelsinki University Central Hospital
Last Modified on26 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

severe milk, peanut or egg allergy verified with positive symptom history, skin prick tests and serum IgE tests and a challenge test

Exclusion Criteria

instable cerebrovascular or heart disease, active autoimmune disease or cancer, or current use of betablockers
poorly controlled asthma or FEV1 < 70% (FEV1< -2SD)
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