Last updated on September 2018

Multicentric Randomised Trial for Resectable Gastric Cancer

Brief description of study

The CRITICS-II trial aims to identify the optimal preoperative regimen in resectable gastric cancer by comparing three investigational treatment arms: chemotherapy vs. chemotherapy and subsequent chemoradiotherapy vs. chemoradiotherapy. The rationale behind this trial design is based on the following concepts:

  • Preoperative treatment is associated with better patient compliance than postoperative regimens
  • Preoperative treatment increases the likelihood of disease downsizing/downstaging and radical R0 resections
  • Preoperative paclitaxel/carboplatin-based concurrent chemoradiotherapy and DOC chemotherapy are effective, feasible and safe regimens

Clinical Study Identifier: NCT02931890

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Catharina Ziekenhuis

Eindhoven, Netherlands
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Maxima Medisch Centrum

Eindhoven, Netherlands
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Recruitment Status: Open

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