Sequential Conditioning in Haploidentical Transplantation for Hematopoietic Stem Cells in Patients With Relapsed or Refractory Lymphoid Hematological Disorders

  • STATUS
    Not Recruiting
  • participants needed
    40
  • sponsor
    Association for Training, Education, and Research in Hematology, Immunology, and Transplantation
Updated on 3 October 2022

Summary

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only treatment option with a significant chance of healing in lymphoid hematological refractory or multiple relapses after chemotherapy. However, all patients with an indication of allo-HSC can not benefit because of two limitations: the toxicity of the treatment and graft shortage available.

For patients refractory or in relapses with an indication of allo-HSC, used the combinaison of an SET followed by the reduced-intensity allo-HSC (RIC) has shown some interesting results.

A post-transplant immune modulation with prophylactic injections of donor lymphocytes (PDLI) showed its effectiveness to decrease the risk of relapse while having a lower toxicity than chemotherapy

Details
Condition Refractory or Relapsed Lymphoid Haemopathy
Treatment Sequential Packaging (SET), Transfusion graft, Prevention of GVHD, Care supports, Lymphocyte injection of prophylactic donor (PDLI)
Clinical Study IdentifierNCT03079089
SponsorAssociation for Training, Education, and Research in Hematology, Immunology, and Transplantation
Last Modified on3 October 2022

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