Last updated on May 2019

Treatment of Latent Tuberculosis in Socially Marginalised Citizens


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Patient Compliance
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Reporting to be homeless (independent of whether the person has an official address) or regularly seeking homeless shelters or public institutions to supply basic needs
  • LTBI defined by positive IGRA test
  • Found plausible by study doctor that the person has been exposed to tuberculosis within 2 years
  • Aged 18 years or older

Exclusion Criteria:

  • Previously treated for tuberculosis
  • Pregnant or breastfeeding
  • Active tuberculosis (evaluated by chest x-ray and examination by a trained doctor)
  • Unable to give informed consent
  • Tested positive for LTBI as part of contact investigation where the index case has or is suspected to have INH of RIF resistant TB
  • Known HIV on antiretroviral treatment
  • Porphyria
  • Known allergy to rifamycins or isoniazid
  • Known epilepsy
  • Known liver disease causing affected liver parameters (ALAT, alkaline phosphatase, bilirubin, INR)
  • Any lab abnormality, disease, concomitant medication or condition that, in the opinion of the investigator, excludes a person from participating

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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