Evaluating the Role of Neuroinflammation in Low Back Pain

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  • sponsor
    Marco Loggia
Updated on 22 September 2021
back pain
brain imaging
low back pain
acute back pain


In this research, the study team will use brain imaging to evaluate the presence of neuroinflammation in the brains and spinal cords of patients with low back pain. The efficacy of minocycline use for low back pain treatment will also be evaluated by observing whether short-term minocycline administration will reduce neuroinflammation and low back pain symptoms.


The goal of this research study is to evaluate whether the central nervous systems of those with low back pain are different from those of healthy, pain-free individuals. Specifically, the researchers will test whether "glial cells" (the immune cells of the brain and spinal cord) are more active in patients with low back pain than in healthy volunteers. The investigators' previous study showed that patients with chronic low back pain demonstrated elevations in brain levels of the 18kDa translocator protein (TSPO), a marker of glial activation.

To test this hypothesis, the study team will image the brains and spinal cords of patients suffering from low back pain using integrated magnetic resonance- positron emission tomography (MR-PET), and a radiotracer called [11C]PBR28, which tracks levels of glial activation.

The efficacy of minocycline as a treatment for chronic low back pain will also be evaluated. A recent study demonstrated a statistically significant reduction in pain in those with lumbar radiculopathy after treatment with minocycline, leading the investigators of this study to believe that minocycline may have potential efficacy in treating other back pain populations.

The study team will observe whether a short course of minocycline hydrochloride may reduce glial activation along with self-reported low back pain symptoms. To this end, patients will be evaluated clinically and/or re-scanned after completing a 2-week trial of minocycline or placebo (a sugar pill).

This study will be enrolling individuals who have been suffering from sub-acute (short-term) and chronic low back pain.

Condition chronic pains, Back Pain, backpain, Low Back Pain, lumbago, Pain, Chronic, Pain, Pain (Pediatric), Lower Back Pain, Back Pain Lower Back Chronic, Chronic Lower Back Pain, backache, Chronic Pain, Post-Surgical Pain, Chronic Back Pain
Treatment Placebo Capsule, Minocycline Hydrochloride 100mg Capsule, Magnetic Resonance-Positron Emission Tomography Imaging
Clinical Study IdentifierNCT03106740
SponsorMarco Loggia
Last Modified on22 September 2021


Yes No Not Sure

Inclusion Criteria

the ability to give written informed consent
fluency in English
on a stable pain treatment
Chronic or sub-acute low back pain

Exclusion Criteria

no interventional pain procedures during drug trial
contraindications to MRI and PET scanning (including presence of a cardiac pacemaker or pacemaker wires, metallic particles in the body, vascular clips in the head or previous neurosurgery, prosthetic heart valves, claustrophobia)
pregnancy or breast feeding
any use of recreational drugs in the past 6 months
allergy to minocycline or other tetracyclines, or taking medications known to interact with minocycline
any other contraindications to minocycline administration
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