Scrub Typhus Infection Induced Cardiovascular Disease

  • STATUS
    Recruiting
  • End date
    Aug 30, 2023
  • participants needed
    100
  • sponsor
    Eulji University Hospital
Updated on 27 April 2022
cardiovascular disease

Summary

Scrub typhus infection has been considered as seasonal and endemic infectious disorder with benign feature. However, the increasing mortality rate of scrub typhus has been recently reported in Southeast Asia and cause of death could be a fetal complicating cardiovascular disease. Therefore, the association and predictors for scrub typhus induced cardiovascular disease should be investigated to provide a timely and appropriate diagnosis and to reduce the mortality rate of complicated scrub typhus infection. Therefore, investigators prospectively investigate the association and predictors of cardiovascular disease in the participants with scrub typhus infection.

Description

Scrub typhus is a zoonotic disease caused by Orientia tsutsugamushi confined to East Asia including South Korea. It is characterized by fever, headache, rash, and eschar and the majority of patients without complications can recover with an early diagnosis and proper management with antibiotics. However, the increasing mortality rate of scrub typhus has been recently reported in Southeast Asia. Severe complications can be manifested by respiratory distress syndrome, renal failure, hepatic failure, and cardiovascular disease. Especially, cardiovascular complications can lead to cardiogenic shock and sudden cardiac arrest. Therefore, the association and predictors for scrub typhus induced cardiovascular disease should be investigated to provide a timely and appropriate diagnosis and to reduce the mortality rate of complicated scrub typhus infection. Therefore, investigators prospectively investigate the association and predictors of cardiovascular disease in the participants with scrub typhus infection admitted to 3rd referral centers in South Korea.

Details
Condition Scrub Typhus, Cardiovascular Complication
Treatment No intervention
Clinical Study IdentifierNCT03274869
SponsorEulji University Hospital
Last Modified on27 April 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

any participants with scrub typhus infection

Exclusion Criteria

patients under age of 18
pregnancy
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