Cerebellar Stimulation and Cognitive Control

  • days left to enroll
  • participants needed
  • sponsor
    Krystal Parker, PhD
Updated on 26 January 2021
bipolar disorder
depressed mood
transcranial magnetic stimulation
cognitive deficits
major depressive disorder


The purpose of this study is to examine whether cerebellar stimulation can be used to improve cognitive deficits and mood in patients with schizophrenia, autism, bipolar disorder, Parkinson's disease, and major depression.


Our recent work found that patients with Parkinson's disease and schizophrenia have impaired frontal EEG rhythms in the theta and delta range (1-8 Hz).We have been using transcranial direct current stimulation to recover these rhythms as patients perform elementary cognitive tasks. We found that although we are able to modulate cerebellar and frontal activity with tDCS, this effect is minimal as the depth of the current is not great enough to modulate all cerebellar activity. Here we use transcranial magnetic stimulation (TMS) to modulate neural activity in the frontal cortex and recover cognitive function in patients with autism, schizophrenia, bipolar disorder and Parkinson's disease.

The purpose of the study is to explore cerebellar stimulation as a potential new treatment to restore frontal activity and cognitive function in autism, schizophrenia, bipolar disorder and Parkinson's disease.Subjects will be brought in for 5 to 6 separate visits, with cerebellar or sham TMS stimulation twice per day for 5 days, as well as 3 follow-up visits.During these visits the patient will have cognitive, disease-specific and emotional testing, including EEG testing and MRI imaging. For those participants that received sham stimulation we will again use EEG to record how single pulses of magnetic or electrical stimulation influences other regions of the cerebellum and downstream brain regions. These data will provide insight into how the cerebellum may influence downstream brain regions and play a role in cognitive and motor performance. All data will be analyzed offline to determine if performance on the interval timing task and/or frontal brain rhythms change following transcranial magnetic stimulation as compared to the pre-stimulation blocks of trials. Additionally, we will analyze changes in their cognitive function, symptom ratings, functional and structural MRI, and mood following stimulation. Controls will receive both active and sham treatment for comparison.

Condition Pervasive developmental disorder, Endogenous depression, Depression, Bipolar Disorder, Schizophrenia, Parkinson's disease, Depression (Major/Severe), Depression (Adolescent), Depression (Pediatric), Depression (Adult and Geriatric), Depression (Treatment-Resistant), Schizophrenia and Schizoaffective Disorders, Depressed, Bipolar Disorders (Pediatric), Schizophrenia and Schizoaffective Disorders (Pediatric), Autism Spectrum Disorder (ASD), Manic Disorders, Autism Spectrum Disorder, autism spectrum disorders, depressive disorder, schizophrenia disorders, parkinson's, parkinson disease, depressed mood, miserable, depressive disorders
Treatment Repetitive Transcranial Magnetic Stimulation (rTMS), Sham Repetitive Transcranial Magnetic Stimulation (rTMS)
Clinical Study IdentifierNCT03217110
SponsorKrystal Parker, PhD
Last Modified on26 January 2021


Yes No Not Sure

Inclusion Criteria

A clinical diagnosis consistent with enrollment

Exclusion Criteria

History of recurrent seizures or epilepsy
Any other neurological or psychiatric diagnosis outside the diagnosis for which the participant is enrolled
Active substance use disorder in the past 6 months other than tobacco use disorder
Inability to consent for study
Coronary Stent
Uncontrolled high blood pressure
Atrial fibrillation
Significant heart disease
Hemodynamic instability
Kidney disease
Pregnant, trying to become pregnant, or breast feeding
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