O2 Tension During TAVI

  • End date
    Dec 20, 2022
  • participants needed
  • sponsor
    Seoul National University Hospital
Updated on 17 November 2021


Hyperoxemia can produce various complications including oxidative stress and myocardial injury. We hypothesized that the normoxic group would have lower myocardial injury compared to hyperoxic group after transcatheter aortic valve replacement.


Hyperoxemia can produce various complications, such as excessive oxidative stress, hyperoxia-induced vasoconstriction, increased perfusion heterogeneity, and resultant myocardial injury. Previous studies have been observed higher mortality in patient group maintained with supranormal oxygenation after resuscitation from cardiac arrest. However, the effect of hyperoxia vs. normoxia on myocardial injury during transcatheter aortic valve replacement (TAVR) has not been well investigated. We hypothesized that the normoxic group would have lower myocardial injury compared to hyperoxic group after TAVR.

Condition Troponin
Treatment normal inspired oxygen fraction, high inspired oxygen fraction
Clinical Study IdentifierNCT03291210
SponsorSeoul National University Hospital
Last Modified on17 November 2021


Yes No Not Sure

Inclusion Criteria

Scheduled for transcatheter aortic valve replacement due to aortic stenosis

Exclusion Criteria

Transapical approach
Pre-procedural PaO2 < 65 mmHg or oxygen support therapy
Pre-procedural severe kidney injury (end-stage renal disease)
Pre-procedural chronic pulmonary disease, symptomatic asthma
Pre-procedural Tb-destroyed lung
Lung cancer
History of acute coronary syndrome within 6 months
History of stroke or transient ischemic attack within 6 months
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