O2 Tension During TAVI

  • STATUS
    Recruiting
  • End date
    Dec 20, 2022
  • participants needed
    72
  • sponsor
    Seoul National University Hospital
Updated on 17 November 2021

Summary

Hyperoxemia can produce various complications including oxidative stress and myocardial injury. We hypothesized that the normoxic group would have lower myocardial injury compared to hyperoxic group after transcatheter aortic valve replacement.

Description

Hyperoxemia can produce various complications, such as excessive oxidative stress, hyperoxia-induced vasoconstriction, increased perfusion heterogeneity, and resultant myocardial injury. Previous studies have been observed higher mortality in patient group maintained with supranormal oxygenation after resuscitation from cardiac arrest. However, the effect of hyperoxia vs. normoxia on myocardial injury during transcatheter aortic valve replacement (TAVR) has not been well investigated. We hypothesized that the normoxic group would have lower myocardial injury compared to hyperoxic group after TAVR.

Details
Condition Troponin
Treatment normal inspired oxygen fraction, high inspired oxygen fraction
Clinical Study IdentifierNCT03291210
SponsorSeoul National University Hospital
Last Modified on17 November 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Scheduled for transcatheter aortic valve replacement due to aortic stenosis

Exclusion Criteria

Transapical approach
Pre-procedural PaO2 < 65 mmHg or oxygen support therapy
Pre-procedural severe kidney injury (end-stage renal disease)
Pre-procedural chronic pulmonary disease, symptomatic asthma
Pre-procedural Tb-destroyed lung
Lung cancer
History of acute coronary syndrome within 6 months
History of stroke or transient ischemic attack within 6 months
Refuse to participate
Pregnant
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