PSMA PET and MRI in Gynecological Cancers

  • End date
    Aug 1, 2023
  • participants needed
  • sponsor
    University of Wisconsin, Madison
Updated on 29 May 2022
Accepts healthy volunteers


The goal of this research is to determine the accuracy of PSMA positron emission tomography (PET) and multi-parametric magnetic resonance (MR) imaging to detect the presence of gynecological cancer cells in the body.


The investigators will evaluate a novel second-generation low-molecular-weight prostate specific membrane antigen (PSMA)-based positron emission tomography (PET) agent, 18F-DCFPyL, to determine the presence or absence of cancer, the accurate distribution of cancer and the normal biodistribution of PSMA in the abdomen and pelvis on PET imaging.

PSMA, also known as folate hydrolase 1 and glutamate carboxypeptidase II, is an enzyme associated with prostate cancer but has been also found to be expressed in the tumor neovasculature of many different types of non-prostate cancer tumors. PSMA-based 18F-DCFPyL PET demonstrates very high tumor-to-background ratio when studied in other tumors, including prostate tumors.

MR imaging is a highly sensitive and specific imaging modality that can be used for gynecologic cancers. MR images can be obtained in conjunction with PSMA PET, adding additional anatomic and multi-parametric MRI information without the need for a second imaging appointment.

Condition Gynecologic Cancer
Treatment PSMA-based 18F-DCFPyL PET tracer
Clinical Study IdentifierNCT03302156
SponsorUniversity of Wisconsin, Madison
Last Modified on29 May 2022


Yes No Not Sure

Inclusion Criteria

Women with or without suspected gynecological cancer
No contraindications for MR or PET imaging
Greater than or equal to 18 years of age
Inclusion Criteria for gynecological cancer patients (N=40)
Women with known or suspected gynecological cancer
No contraindications for MR or PET imaging
Greater than or equal to 18 years
Have had or are scheduled to undergo a hysterectomy and/or salpingo-oophorectomy

Exclusion Criteria

Women that are pregnant or breast-feeding
Age <18
Inability to provide informed consent on their own behalf
Severe kidney dysfunction (GFR <30 mL/min/1.73m2)
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