Neurophysiological Study of Sensory and Cognitive Processes in Healthy Children and Adults (PROSCEA)

  • End date
    Jun 21, 2027
  • participants needed
  • sponsor
    University Hospital, Tours
Updated on 7 October 2022
Accepts healthy volunteers


It is now widely accepted that autism is linked to a developmental disorder and cerebral function.

Our research team (UMR U930 INSERM, François-Rabelais University of Tours, whom Pr F Bonnet-Brilhault is responsible for team "Autism") hypothesizes that atypical sensory information processing, especially auditory and / or visual information, could underly the symptoms observed in autism. A better knowledge of the typical development of the sensory and cognitive processes must therefore make it possible in the long term to identify the abnormalities linked to the autism spectrum disorders (ASD).

Studies in healthy subjects are therefore necessary in order to identify neurophysiological indices of cerebral functioning and to study their evolution during normal development, making it possible in the future to compare with populations of subjects with ASD.

The investigators intend to study the development of all the cognitive processes involved in the processing of sensory and, in particular, auditory and visual information in humans: from low-level perception processes to higher-level cognitive processes (attention, emotion, language, prediction, ...). For this the investigators will use non-invasive neurophysiological explorations (EEG, eye tracking) as well as neuropsychological explorations (Questionnaires or spontaneous language recording).

A better understanding of the pathophysiological mechanisms underlying the symptoms observed in autism could ultimately lead to the development of new specific therapeutic strategies, particularly in the field of exchange and development therapy or cognitive remediation .

Condition Healthy Volunteer
Treatment Neuropsychological assessment, Neurophysiological assessment
Clinical Study IdentifierNCT03182400
SponsorUniversity Hospital, Tours
Last Modified on7 October 2022


Yes No Not Sure

Inclusion Criteria

Between 1 and 60 years-old
Able to understand and apply instructions for a task
Information of subject or legal representant
Informed written consent of subject or legal representant
Affiliation to the social security system

Exclusion Criteria

Abnormal corrected vision
Abnormal audition
Known personal neurological pathology
Known personal psychiatric problems
Identified difficulties for walking, language, or learning
Exclusion period because of participation to another experimental protocol
Adult with legal protection
Clear my responses

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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