Last updated on February 2018

Sigh in Acute Hypoxemic Respiratory Failure


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Respiratory Failure | ADULT RESPIRATORY DISTRESS SYNDROME
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • patients intubated since >24 hours and 7 days,
  • undergoing PSV since >4 and 24 hours,
  • PaO2/FiO2 ratio 300 mmHg (measured at clinical positive end-expiratory pressure [PEEP] and FiO2 values)
  • clinical PEEP 5 cmH2O,
  • Richmond Agitation-Sedation Scale (RASS) value of -2 to 0

Exclusion Criteria:

  • patients with PEEP 15 cmH2O;
  • PaCO2 >60 mmHg;
  • Arterial pH <7.30;
  • Age <18 year-old;
  • PaO2/FiO2 ratio 100 mmHg (measured at clinical PEEP and FiO2 values);
  • central nervous system or neuromuscular disorders;
  • history of severe chronic obstructive pulmonary disease or fibrosis;
  • AHRF fully explained by cardiac failure or fluid overload (e.g., left ventricle ejection fraction 40% with no other risk factor);
  • impossibility to titrate sedation to desired RASS value of -2 to 0;
  • evidence of active air leak from the lung (e.g., pneumothorax);
  • cardiovascular instability (e.g., systolic blood pressure [SBP] <90 mmHg despite vasopressors);
  • clinical suspect of elevated intracranial pressure;
  • extracorporeal support;
  • moribund status;
  • refusal by the attending physician.

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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