Last updated on March 2019

Therapeutic Effect and Mechanism of Acupuncture Treating Chronic Pain and Major Depression Comorbidity

Brief description of study

Objectives: The effect of acupuncture as treatment for chronic pain and depression comorbidity is questionable because only a limited number of controlled clinical trials with sound methodologies have been conducted. The investigators will perform a well-designed crossover study including assessments of scales and blood sample analysis to investigate the efficacy of acupuncture as treatment for comorbidity of chronic pain and major depression disorder (MDD) and figure out the indicative biomarkers to predict or assess the comorbidity.

Methods: Patients with a recent major depression and chronic pain were randomized to receive acupuncture for depression group or acupuncture for chronic pain. They will receive 2~3 sessions per week over 6 consecutive weeks. Then patients accept another 6weeks sessions after two-week washout. During washout period, original western treatment will be maintained and acupuncture will be interrupted.

The primary outcome measure was change in 21-item Hamilton Depression Rating Scale (HAMD), pain with Brief Pain Inventory- Long form (BPI). Secondary outcome measures included changes in Beck Depression Inventory-II (BDI-II), Neurotoxicity Rating Scale (NTRS), WHO Quality of Life (WHOQoL), Clinical Global Impression (CGI), biomarkers such as neurotransmitter, kinase, protein, cytokine, DNA, mRNA related to comorbidity of chronic pain and major depression.

Clinical Study Identifier: NCT03328819

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