Effects of Transcranial Direct Current Stimulation (tDCS) on Brain Organization and Motor Recovery After Stroke (ESTCORM)

  • End date
    Sep 30, 2023
  • participants needed
  • sponsor
    Adrian Guggisberg
Updated on 20 October 2022
transcranial direct current stimulation
hemorrhagic stroke
neurological rehabilitation


Neurological deficits and motor disorders are extremely common after stroke. Physical therapies can improve the autonomy of these patients, but despite an intensive stationary neurorehabilitation, severe deficits often persist. Complementary therapies that could improve recovery would therefore be very welcome.

Transcranial direct current stimulation (tDCS) induces, in a non-invasive way, a transient inhibitory or excitatory neuromodulation of certain cerebral regions. An increasing number of studies show that this modulation of brain activity can improve motor functions in patients with brain lesions and increase the effect of physical therapies. However, the "optimum" configuration of tDCS and the induced effects remain to be characterized and investigated.

The investigators therefore propose to carry out a study including a pilot phase in order to determine the most efficient tDCS setup. The optimum setup of of the pilot phase will be compared to a placebo condition in a multicentric main study.

Condition Stroke
Treatment DC-stimulator (Neuroconn, Germany)
Clinical Study IdentifierNCT03342534
SponsorAdrian Guggisberg
Last Modified on20 October 2022


Yes No Not Sure

Inclusion Criteria

Ischemic or hemorrhagic stroke
≤ 4 weeks after stroke onset
Paresis of upper limb with Fugl-Meyer score between 15 and 55 at study entry
Capable of participating during treatment sessions of 30-60 minutes
Informed consent obtained

Exclusion Criteria

Incapacity to understand study information or task instructions during trial
New additional stroke during rehabilitation
Reduced vigilance or delirium
Severe language deficits
Preexisting affection of an upper limb
Severe spasticity or dystonia
Severe co-morbidities (e.g., traumatic, rheumatologic, neurodegenerative disease)
Skull breach
History of seizures or epilepsy
Metallic object in the brain
Other contraindication to non-invasive brain stimulation
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