Intraductal Secretin Stimulation Test: What Is the Proper Collection Time?

  • days left to enroll
  • participants needed
  • sponsor
    Indiana University
Updated on 1 September 2021


The aim is to evaluate the peak secretory flow rates and bicarbonate concentrations as determined by a 30 minute intraductal secretin stimulation test in patients with a low likelihood of pancreatic pathology and to compare these data to those obtained from our historical patients with suspected chronic pancreatitis. These will be patients in which inadvertent pancreatic cannulation occurs during therapeutic endoscopic retrograde cholangiopancreatography (ERCP) for biliary indications . All study subjects will receive a 5 day follow-up phone call. Enrollment goal is 36 subjects.

Condition Endoscopic Retrograde Cholangiopancreatography
Treatment Human Secretin for injection 16 mcg
Clinical Study IdentifierNCT03263481
SponsorIndiana University
Last Modified on1 September 2021


Yes No Not Sure

Inclusion Criteria

Male or female patients 18 years of age referred to Indiana University Health, University Hospital for ERCP for a biliary indication, at the discretion of the treating MD (e.g. suspected common bile duct stone, initial post-liver transplant evaluation, suspected or confirmed cholangiocarcinoma, suspected primary sclerosing cholangitis -- see exclusion criterion #12)

Exclusion Criteria

Pregnant woman or breast feeding
Age <18 years
Patient unable to give informed consent
Patient with a history of pancreatic surgery
Patient with a history of pancreatic cancer
Patient with a history of acute or chronic pancreatitis
Patient with radiographic evidence of acute or chronic pancreatitis on CT, MRCP, or EUS
Patient with a current or prior history of average daily alcohol consumption of greater than 60 g per day for more than 2 years
Patient with a history of cigarette smoking greater that 20 pack-years
Patient with a history of pancreas divisum
Evidence of chronic pancreatitis on pancreatogram during ERCP
ERCP for an isolated biliary indication with previous biliary sphincterotomy or for biliary stent exchange, when pancreatic entry should easily be avoided by the endoscopist
History of allergy or adverse reactions to secretin
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