Risk-Reducing Surgeries for Hereditary Ovarian Cancer

  • End date
    Sep 1, 2023
  • participants needed
  • sponsor
    Lei Li
Updated on 21 January 2021


Based on studies of "Inherited Susceptible Genes Among Epithelial Ovarian Cancer" (NCT03015376, clinicaltrials.gov) and "Cohort Study of Universal Screening for Lynch Syndrome in Chinese Patients of Endometrial Cancer" (NCT03291106, clinicaltrials.gov), we provide risk-reducing surgeries of salpingo-oophorectomy with/without hysterectomy for healthy carriers with mutation genes of hereditary ovarian cancer, which is defined ovarian cancer with relevant pathogenic mutations.

Condition Hysterectomy, Lynch Syndrome, Breast Cancer, Breast Cancer, Ovarian Cancer, Ovarian Cancer, Recurrent Ovarian Cancer, Oophorectomy, Hereditary Neoplastic Syndrome, Hereditary Cancer Syndromes, Hereditary Breast and Ovarian Cancer, Recurrent Ovarian Cancer, Hereditary Breast and Ovarian Cancer Syndrome, Hereditary Cancer Syndromes, hysterectomies, ovariectomy
Treatment follow-up, salpingo-oophorectomy only by laparoscopy, salpingo-oophorectomy with hysterectomy by laparoscopy
Clinical Study IdentifierNCT03294343
SponsorLei Li
Last Modified on21 January 2021


Yes No Not Sure

Inclusion Criteria

Carriers with known and definite mutation genes of hereditary ovarian cancer
With children and without further requirement of pregnancy
No less than 35 years for carriers with mutation gene of BRCA1
No less than 40 years for carriers with mutation gene of BRCA2
No less than 45 years for carriers with mutation genes of BRIP1, RAD51C, RAD51D and RAD51
No less than 50 years for carriers with mutation genes of ATM, MSH2, MLH1, SH6, PMS2, EPCAM and STK11

Exclusion Criteria

Without children
Not reaching appreciate ages
With contraindications of laparoscopy
Refusal of risk-reducing surgeries
Clear my responses

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