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graft versus host disease
granulocyte colony stimulating factor
refractory acute myeloid leukemia (aml)
secondary acute myeloid leukemia
hematopoietic growth factors
This is a pilot study using decitabine and vorinostat before and during chemotherapy with
fludarabine, cytarabine and G-CSF (FLAG).
Decitabine is a demethylating agent and vorinostat is a HDAC inhibitor. The use of
demethylating agents and HDAC inhibitors in combination have been previously shown to have
synergistic effects in altering neoplastic pathways of cancer cells and be well tolerated in
human clinical studies. With the ability of decitabine and vorinostat to alter the abnormal
cellular pathways of leukemic blasts and essentially turn off anti-apoptotic proteins, the
leukemia cells have become primed for cytotoxic cell kill via chemotherapeutic agents. This
study will ask the question as to whether or not the combination of decitabine and vorinostat
followed by chemotherapy is feasible and whether it can positively impact outcome in patients
with relapsed or refractory acute myelogenous leukemia.
If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.
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