Last updated on June 2018

Feasibility and Safety of Umbilical Cord Blood Transfusion in the Treatment of Neonatal Cerebral Ischemia and Anemia

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Cerebral Ischemia of Newborn | Hypoxic Brain Damage | Hypoxia Neonatal | Neonatal anemia
  • Age: - 1 Years
  • Gender: Male or Female

Inclusion Criteria:

  • evidence of asphyxiation, defined by 5-minute Apgar score 5;
  • evidence of HIE, defined by UCB pH <7.15 or base excess 10mM;
  • subjects with HIE confirmed by clinical features and initial investigations;
  • subjects with evidence of anemia, defined by hematocrit < 40% or hemoglobin 13g/dL within the first 96 hours of life;
  • obtain the informed consent from parents

Exclusion Criteria:

  • congestive cardiac failure;
  • microcephaly, anencephaly, encephalocele, or other abnormality
  • conjoint twins;
  • chromosomal disorders
  • fetal alcohol syndrome
  • spinal bifida or other neural tube defects
  • subjects have other neurological deficit conditions
  • polycythemia
  • congenital hematological malignancy
  • investigator decision

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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