Collecting Information About Treatment Results for Patients With Cushing's Syndrome

STATUS

Recruiting
End date

Nov 28, 2024
participants needed

200
sponsor

Memorial Sloan Kettering Cancer Center

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Updated on 26 March 2022

See if I qualify

remission

pituitary

depression

anxiety

dexamethasone

laboratory reports

adrenal neoplasm

ACTH

corticotropin

cushing's syndrome

free cortisol

urinary free cortisol

inferior petrosal sinus sampling

Summary

The purpose of this study is to follow participants with Cushing's syndrome during the course of their routine care and to form a data registry to study long term participant outcomes.

Details

Condition	Cushing's Disease, Cushing Syndrome, Cushing Disease
Treatment	Cushing's QoL (Quality of Life Questionnaire), Nottingham Health Profile (NHP), Hospital Anxiety and Depression Scale (HADS), Perceived Stress Scale (PSS), Barratt's Impulsivity Scale (BIS), Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), State Food Craving Questionnaire-State (FCQ-S), Trait Food Craving Questionnaire-Trait (FCQ-T), Visual Analogue Scale (VAS), Sensitivity to Reinforcement of Addictive and other Primary Rewards (STRAP-R) food variant
Clinical Study Identifier	NCT03364803
Sponsor	Memorial Sloan Kettering Cancer Center
Last Modified on	26 March 2022

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Eligibility		Yes	No	Not Sure
Inclusion Criteria
	Age 14 or older
	Active or treated Cushing's (due to pituitary, ectopic, or adrenal tumor)
	The diagnosis of CS will be made by the PI, based on the below Endocrine Society guidelines, the patient's clinical presentation, and the PI's judgment
	° Diagnostic criteria for pituitary CD are according to the Endocrine Society
	guidelines and include: Elevated 24-hour urinary free cortisol (UFC), normal
	or elevated plasma ACTH, elevated midnight salivary cortisol levels, or
	classic dexamethasone suppression testing for CD (morning cortisol > 5 ug/dL
	after 1 mg overnight of classic 2-day low dose test) and a pituitary lesion on
	MRI. If patient does not have any of these results, pathology of ACTH tumor
	may confirm presence of disease
	For pituitary patients, if the patient demonstrates non-classic testing or no pituitary lesion is seen on MRI then petrosal sinus sampling or positive surgical pathology will be used to confirm pituitary source of Cushing's. Clinical or biochemical remission after surgery will also confirm pituitary source
	Ectopic Cushing's will be confirmed by petrosal sinus sampling and appropriate imaging tests, or positive surgical pathology
	Adrenal Cushing's will be confirmed by a suppressed plasma ACTH value and identification of an adrenal lesion on CT or MRI, or positive surgical pathology
	In lieu of MRI, surgical, or laboratory reports, physician's assessment note including mention of results will also be used as source for eligibility purposes
Exclusion Criteria
	Patients with a diagnosis of iatrogenic Cushing's

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Step 3 Enroll in the clinical study

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Step 4 Get your study results

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Collecting Information About Treatment Results for Patients With Cushing's Syndrome