Last updated on March 2019

Studies in Patients With Defecatory Disorders

Brief description of study

Defecatory disorders like chronic constipation and faecal incontinence affect 25% of the population with rising incidence. Defecatory disorders pose a major health care burden and are poorly recognized and treated. The need for better diagnostics and therapeutics is substantial. Currently management options for these patients are limited, partly due to the fact that control of defaecation and continence is multifactorial but also due to the fact that it is difficult to identify the exact cause of patients' incontinence.

Current assessment of patients with constipation and faecal incontinence include endoscopic assessment to rule out intraluminal organic cause for patients' symptoms, endoanal ultrasound scan / MRI to assess patients' pelvic floor anatomy and anorectal manometry to assess anorectal function. All tests are susceptible to measurement artifacts, with a high inter-individual variation with significant overlap between healthy asymptomatic and symptomatic patients.

Endoluminal Functional Lumen Imaging Probe (EndoFLIP) is a novel technology, originally used to measure the dimensions and function of a hollow organ. The proposed study intends to use a modified EndoFLIP to integrate several technologies into one which will save time and reduce test variability. A major difference from previous EndoFLIP studies are that the device will be defecated rather than providing static data from one location in the anal canal.

In the proposed studies investigators will assess defecatory function in subgroups of Hong Kong patients suffering from chronic constipation and faecal incontinence and determine biomarkers to increase the diagnostic value of anorectal testing. Investigators will study up to 70 patients with anorectal disorders and 40 healthy control subjects. Investigators anticipate to improve diagnostics of anorectal disorders considerably.

Clinical Study Identifier: NCT03317938

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