Stimulation of the Rostral Zona Incerta for Parkinson's Disease

  • End date
    Dec 19, 2022
  • participants needed
  • sponsor
    University of Colorado, Denver
Updated on 19 October 2021
brain stimulation


Patients with Parkinson's Disease who undergo Deep Brain Stimulation surgery receive symptom relief due to electrical stimulation of the brain. The target for the stimulation, in many cases, is the subthalamic nucleus (STN). The brain area just above the STN is called the rostral Zona Incerta (rZI). The rZI may be a potential target for deep brain stimulation, in combination with the STN.


Deep brain stimulation (DBS) of an area of the brain called the subthalamic nucleus (STN) is an effective treatment in Parkinson's disease (PD). However, stimulating the STN can lead to unwanted side effects that involve muscle movements (dyskinesias) and behavior and mood problems. DBS of a different brain structure, called the rostral zona incerta (rZI), has been demonstrated to be as effective as stimulating the STN, without any unwanted side effects in several studies. However, there is great variability in reported efficacy and adverse effects of rZI stimulation likely due to challenges in locating this area in the brain. The goals of this study are 1) to develop an improved method for targeting the rZI 2) determine efficacy of rZI with STN stimulation compared with STN stimulation alone, 3) evaluate any stimulation adverse effects of combined stimulation of the rZI and STN.

Condition Parkinson's disease, parkinson's, parkinson disease
Treatment Deep brain stimulation
Clinical Study IdentifierNCT03212885
SponsorUniversity of Colorado, Denver
Last Modified on19 October 2021


Yes No Not Sure

Inclusion Criteria

Parkinson's Disease
No current deep brain stimulating electrodes

Exclusion Criteria

Other movement disorders
Parkinson's Disease with already implanted electrode
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