Combined Breast MRI and Biomarker Strategies in Identifying High-risk Breast Cancer Patients
-
- STATUS
- Recruiting
-
- End date
- Oct 1, 2023
-
- participants needed
- 650
-
- sponsor
- City of Hope Medical Center
Summary
This clinical trial studies normal breast tissue changes combined with breast magnetic resonance imaging (MRI) that may suggest the beginnings of cancer development. Using breast tissue markers in combination with breast imaging such as MRI may help to more accurately assess a woman's risk of developing breast cancer.
Description
PRIMARY OBJECTIVES:
I. To determine the number of high risk women with abnormal screening breast MRI and morphologically normal biopsy over 7 years.
SECONDARY OBJECTIVES:
I. To determine if WNT10B/mutant p53 expression as measured in the 0-month biopsy predicts women with an abnormal MRI/non-cancerous biopsy who will progress to cancer over 7 years.
TERTIARY OBJECTIVES:
I. To determine the predictive accuracy of WNT10B with MRI, of which will be compared with MRI alone using the C-index.
- OUTLINE
Participants undergo standard of care high risk breast cancer screening MRIs at baseline and follow-up and blood sample collection at baseline. Participants undergo collection of breast tissue samples at any breast biopsy or breast surgery.
Details
| Condition | Chronic Diarrhea, Adverse Effects, Drugs, Breast Cancer - HER2 Positive, Primary Immunodeficiency, Brain Function, Metastatic Triple-Negative Breast Cancer, Diet and Nutrition, Peripheral Arterial Occlusive Disease, Skin Wounds, Razor Bumps (Pseudofolliculitis Barbae), Pediatric Health, Near-Sighted Corrective Surgery, Chronic Shoulder Pain, Recurrent Respiratory Papillomatosis, Healthy Subject, Injection Port, Anal Dysplasia, Vaginal Atrophy |
|---|---|
| Treatment | laboratory biomarker analysis, magnetic resonance imaging, biospecimen collection, Biopsy of Breast |
| Clinical Study Identifier | NCT03303846 |
| Sponsor | City of Hope Medical Center |
| Last Modified on | 3 December 2021 |
How to participate?
,
You have contacted , on
Your message has been sent to the study team at ,
What happens next?
- You can expect the study team to contact you via email or phone in the next few days.
- Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.
You are contacting
Primary Contact
Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.
Learn moreIf you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.
Learn moreComplete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.
Learn moreSimilar trials to consider
Browse trials for
Not finding what you're looking for?
Sign up as a volunteer to stay informed
Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.
Sign up as volunteer