The Role and Dynamics of Liver Dysfunction in Patients Undergoing Cardiac Surgery

  • End date
    May 22, 2023
  • participants needed
  • sponsor
    Semmelweis University Heart and Vascular Center
Updated on 22 March 2022


The aim of the present study is the evaluation of the occurrence and effect of hepatic dysfunction on outcome following cardiac surgery, as well as the monitoring of changes in liver haemodynamics in the early postoperative period.


Prospective, consecutive study of patients undergoing cardiac surgery in Heart and Vascular Center, Semmelweis University, Budapest.

Registered data:

  • Anamnestic and demographic data
  • Liver dysfunction prior surgery, etiology of liver dysfunction
  • Perioperative clinical data: laboratory tests, imaging, haemodynamic measures
  • risk prediction score of the American Society of Anesthesiologists(ASA), EUROpean System for Cardiac Operative Risk Evaluation (EuroScore), Acute Physiology and Chronic Health Evaluation II (APACHE II), Simplified Acute Physiology Score (SAPS II), Canadian Cardiovascular Society grading of angina pectoris (CCS)
  • Model for End-Stage Liver Disease (MELD), MELD excluding International Normalised Ratio (INR) (MELD-XI), modified MELD score (modMELD), Child-Pugh

The occurrence and etiology pattern of hepatic impairment are going to be evaluated according to age and type of cardiac illness. Correlations between perioperative haemodynamical alterations and structural, functional changes in hepatic status will be investigated.

The impact of hepatic impairment on surgical outcome is going to be examined by multivariate regression models.

Condition Cardiac Surgery, Hepatic Impairment, Heart Failure
Clinical Study IdentifierNCT02893657
SponsorSemmelweis University Heart and Vascular Center
Last Modified on22 March 2022


Yes No Not Sure

Inclusion Criteria

Patients over 18 years of age admitted for elective cardiac surgical procedures

Exclusion Criteria

Not willing to participate
Pregnant women
During active psychiatric hospital care
Patients with defined legal incapability or limited capability
Non-evaluable patient due to insufficient clinical information
Patients with a transplanted heart
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