Last updated on February 2019

Randomized Phase 2 Study of Pembrolizumab Plus Epacadostat With Platinum-based Chemotherapy Versus Pembrolizumab Plus Platinum-based Chemotherapy Plus Placebo in Metastatic Non-Small Cell Lung Cancer (KEYNOTE-715-05/ECHO-306-05)

Brief description of study

The purpose of this study is to evaluate the efficacy and safety of pembrolizumab plus epacadostat with platinum-based chemotherapy versus pembrolizumab plus platinum-based chemotherapy plus placebo as first-line therapy in participants with metastatic non-small cell lung cancer (NSCLC).

Clinical Study Identifier: NCT03322566

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Western Regional Medical Center, Inc.

Goodyear, AZ United States

Arizona Oncology Associates PC- HOPE

Tucson, AZ United States

Cedars-Sinai Medical Center

Los Angeles, CA United States

Lynn Cancer Institute

Boca Raton, FL United States

Florida Cancer Specialists (South Region)

Fort Myers, FL United States

Florida Cancer Specialists (North Region)

Saint Petersburg, FL United States

Rush University Medical Center

Chicago, IL United States

Northwest Oncology and Hematology

Elk Grove Village, IL United States


Fort Wayne, IN United States

LSU Health of New Orleans

New Orleans, LA United States

Dana-Farber Cancer Institute (Boston)

Boston, MA United States

University of Michigan

Ann Arbor, MI United States

Mayo Clinic

Rochester, MN United States


Saint Louis Park, MN United States

New York Oncology Hematology P.C

Albany, NY United States

Oncology Hematology Care, Inc.

Cincinnati, OH United States

Allegheny General Hospital

Pittsburgh, PA United States

UT Southwestern Medical Center At Dallas

Dallas, TX United States

Texas Oncology-Denton South

Denton, TX United States

Emily Couric Clinical Cancer Center

Charlottesville, VA United States

Seattle Cancer Care Alliance

Seattle, WA United States

West Virginia University

Morgantown, WV United States

MNCCI Port Macquarie Base Hospital

Port Macquarie, Australia

Blacktown Hospital

Blacktown, Australia

Chris OBrien Lifehouse

Camperdown, Australia

Southern Medical Day Care Centre

Wollongong, Australia

Cairns Base Hospital

Cairns, Australia

Frankston Hospital

Frankston, Australia

Cetus Oncologia

Belo Horizonte, Brazil

Lions Gate Hospital

North Vancouver, BC Canada

William Osler Health System

Brampton, ON Canada

Lakeridge Health

Oshawa, ON Canada

Sault Area Hospital

Sault Ste Marie, ON Canada

CIUSSS du Saguenay-Lac-St-Jean

Chicoutimi, QC Canada

CISSS de la Monteregie-Centre

Greenfield Park, QC Canada

Institut Bergonie

Bordeaux, France

Hopital Nord du Marseille

Marseille, France

Hopital Robert Schuman

Metz, France

Clinique Clementville

Montpellier, France

Centre Paul Strauss

Strasbourg, France

Hopital Foch

Suresnes, France

Klinikum Esslingen GmbH

Esslingen, Germany

Krankenhaus Martha Maria

Halle, Germany

Pius Hospital Oldenburg

Oldenburg, Germany

Southern Cancer Center, PC

Daphne, AL United States

St. Luke's Hospital - Anderson Campus

Easton, PA United States

Semmelweis Egyetem

Budapest, Hungary

CEPON Centro de Pesquisa Oncol gicas

São José Do Rio Preto, Brazil

Centre Hospitalier Lyon Sud

Pierre-Bénite, France

Recruitment Status: Closed

Brief Description Eligibility Contact Research Team

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