Postpartum Management of Hypertension in Pregnancy With Hydrochlorothiazide

STATUS

Recruiting
End date

Aug 30, 2023
participants needed

612
sponsor

The University of Texas Medical Branch, Galveston

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Updated on 4 October 2022

See if I qualify

platelet count

hypertension

edema

hydrochlorothiazide

thrombocytopenia

nephropathy

proteinuria

gestational hypertension

maternal hypertension

Summary

Postpartum prophylactic HCTZ administration for prevention and relapse of preeclampsia or gestational hypertension.

Description

To evaluate effectiveness of hydrochlorothiazide prophylaxis on prophylaxis, prevention and relapse of preeclampsia or gestational hypertension on readmission rates, need for additional antihypertensive therapy and number of triage visits.

Details

Condition	Pre-Eclampsia, Gestational Hypertension, Superimposed Pre-Eclampsia, Hypertension, Pregnancy-Induced, Postpartum Pregnancy-Induced Hypertension, Postpartum Preeclampsia
Treatment	Placebo tablet, Hydrochlorothiazide 50mg Tablet
Clinical Study Identifier	NCT03298802
Sponsor	The University of Texas Medical Branch, Galveston
Last Modified on	4 October 2022

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Eligibility		Yes	No	Not Sure
Inclusion Criteria
	Maternal age ≥ 18 years and <50 years
	Diagnosis of gestational hypertension or preeclampsia^ at any time during pregnancy, labor or postpartum
	defined as isolated systolic BP of 140 mm Hg or greater, a diastolic BP of 90 mm Hg or greater, or both) or ^ defines as new-onset hypertension plus new-onset proteinuria, or in the absence of proteinuria, preeclampsia is diagnosed as hypertension in association with thrombocytopenia (platelet count less than 100,000/microliter), impaired liver function (elevated blood levels of liver transaminases to twice the normal concentration), the new development of renal insufficiency (elevated serum creatinine greater than 1.1 mg/dL or a doubling of serum creatinine in the absence of other renal disease), pulmonary edema, or new-onset cerebral or visual disturbances.)
Exclusion Criteria
	Subject requiring antihypertensive therapy at time of screening
	Planned discharge with oral anti-hypertensive medication
	Contraindication to hydrochlorothiazide (advanced renal failure or anuria, hypersensitivity to sulfonamides)
	Subject not able to follow up postpartum
	Lactose intolerance
	Pre-gestational diabetes

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Postpartum Management of Hypertension in Pregnancy With Hydrochlorothiazide