Postpartum Management of Hypertension in Pregnancy With Hydrochlorothiazide

  • End date
    Aug 30, 2023
  • participants needed
  • sponsor
    The University of Texas Medical Branch, Galveston
Updated on 4 October 2022
platelet count
gestational hypertension
maternal hypertension


Postpartum prophylactic HCTZ administration for prevention and relapse of preeclampsia or gestational hypertension.


To evaluate effectiveness of hydrochlorothiazide prophylaxis on prophylaxis, prevention and relapse of preeclampsia or gestational hypertension on readmission rates, need for additional antihypertensive therapy and number of triage visits.

Condition Pre-Eclampsia, Gestational Hypertension, Superimposed Pre-Eclampsia, Hypertension, Pregnancy-Induced, Postpartum Pregnancy-Induced Hypertension, Postpartum Preeclampsia
Treatment Placebo tablet, Hydrochlorothiazide 50mg Tablet
Clinical Study IdentifierNCT03298802
SponsorThe University of Texas Medical Branch, Galveston
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

Maternal age ≥ 18 years and <50 years
Diagnosis of gestational hypertension or preeclampsia^ at any time during pregnancy, labor or postpartum
defined as isolated systolic BP of 140 mm Hg or greater, a diastolic BP of 90 mm Hg or greater, or both) or ^ defines as new-onset hypertension plus new-onset proteinuria, or in the absence of proteinuria, preeclampsia is diagnosed as hypertension in association with thrombocytopenia (platelet count less than 100,000/microliter), impaired liver function (elevated blood levels of liver transaminases to twice the normal concentration), the new development of renal insufficiency (elevated serum creatinine greater than 1.1 mg/dL or a doubling of serum creatinine in the absence of other renal disease), pulmonary edema, or new-onset cerebral or visual disturbances.)

Exclusion Criteria

Subject requiring antihypertensive therapy at time of screening
Planned discharge with oral anti-hypertensive medication
Contraindication to hydrochlorothiazide (advanced renal failure or anuria, hypersensitivity to sulfonamides)
Subject not able to follow up postpartum
Lactose intolerance
Pre-gestational diabetes
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