Anticholinergic Burden - Treatment Optimization

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    Region Skane
Updated on 25 January 2021


There is increasing evidence that medications with anticholinergic effects may adversely affect cognitive function. Older adults are particularly sensitive to anticholinergic effects because of changes in pharmacokinetics and pharmacodynamics. The cumulative effect of taking one or more medicines with anticholinergic properties is referred to as anticholinergic burden. To estimate the anticholinergic burden, Boustani et al. published the Anticholinergic Cognitive Burden scale (2008). The objective of this study is to measure the association between the use of medications with anticholinergic properties (identified by the ACB scale) and cognitive performance. Anticholinergic use and cognitive performance will be measured at baseline and 6-months follow-up.

Condition Anticholinergic Agents, Cognitive Function, anticholinergics, anticholinergic, anticholinergic agent, acetylcholine receptor antagonist, anticholinergic drug
Clinical Study IdentifierNCT03208569
SponsorRegion Skane
Last Modified on25 January 2021


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years and older
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