Safety and Efficacy of Fecal Microbiota Transplantation in a Population With Bipolar Disorder

Inclusion Criteria:

1. Between 18-65 years of age
2. Outpatient status
3. Have a diagnosis of bipolar disorder (BD) (type I or II) according to the Mini International Neuropsychiatric Interview (MINI)
4. Have been on a stable first line treatment for BD depression at an adequate dose for at least 8 weeks prior to study entry
5. Suffer from a current depressive episode (Montgomery-sberg Depression Rating Scale (MADRS) score at screening and baseline of 12)

Exclusion Criteria:

1. DSM-IV criteria for substance abuse within the last 6 months or lifetime dependency
2. Active eating disorders
3. Schizophrenia or schizoaffective disorder
4. Current psychotic symptoms
5. A Young Mania Rating Scale (YMRS) score of 12 at screening
6. Active suicidality
7. Regular intake of non-steroidal anti-inflammatory drugs or iron supplements in the 3 months prior to study entry
8. Use of prebiotics or probiotics for medical purposes, use of antibiotics or any experimental drug in the 3 months prior to study entry
9. Chronic gastrointestinal diseases
10. Conditions causing immunosuppression
11. A significant bleeding disorder
12. Any contraindication to colonoscopy
13. Pregnancy or breastfeeding