Radiotherapy With or Without Concurrent Chemotherapy for Extensive Lymphatic Metastasis of Esophageal Cancer - 3JECROG P-03

  • End date
    Dec 31, 2022
  • participants needed
  • sponsor
    Chinese Academy of Medical Sciences
Updated on 22 January 2021


The investigators aimed to compare elective nodal irradiation versus involved field irradiation with or without concurrent chemotherapy and the addition of consolidation chemotherapy for patients with extensive lymphatic metastasis of esophageal cancer.

Condition IMRT With or Without Concurrent Chemotherapy for Esophageal Cancer
Treatment Paclitaxel, Platinum-Based Drug, SIB-IMRT, Elective Nodal Irradiation (ENI), Involved Field Irradiation (IFI)
Clinical Study IdentifierNCT03328234
SponsorChinese Academy of Medical Sciences
Last Modified on22 January 2021


Yes No Not Sure

Inclusion Criteria

Diagnosis of clinical stage T2-4N0-1M1According to UICC 2002
A untreated squamous esophageal carcinoma
Karnofsky performance status(KPS) 70 and Charlson score 3
Adequate organ function
No known history of drug allergy
Blood routine examination : WBC4.0
hepatic and renal function are normal

Exclusion Criteria

Age 70 or 16
Already received the treatment of chemotherapy or radiotherapy
Pregnant or lactating females
Known drug allergy
Without agreement of informed consent form
Insufficient hepatorenal function or Blood routine examination
Severe cardiovascular diseases, diabetes with uncontrolled blood sugar, mental disorders, uncontrolled severe infection, active ulceration which need intervention
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