Last updated on September 2020

Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors Non-Hodgkin Lymphoma or Histiocytic Disorders With Defects in DNA Damage Repair Genes (A Pediatric MATCH Treatment Trial)

Brief description of study

This phase II Pediatric MATCH trial studies how well olaparib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with defects in deoxyribonucleic acid (DNA) damage repair genes that have spread to other places in the body (advanced) and have come back (relapsed) or do not respond to treatment (refractory). Olaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Detailed Study Description


I. To determine the objective response rate (ORR; complete response + partial response) in pediatric patients treated with olaparib with advanced solid tumors (including central nervous system [CNS] tumors), non-Hodgkin lymphomas or histiocytic disorders that harbor activating genetic alterations in the deleterious genetic alterations in the DNA damage repair (DDR) pathway.


I. To estimate the progression free survival in pediatric patients treated with olaparib with advanced solid tumors including non-Hodgkin lymphomas, CNS tumors, and histiocytosis that harbor deleterious genetic alterations in the DDR pathway.

II. To obtain information about the tolerability of olaparib in children and adolescents with relapsed or refractory cancer.

III. To provide preliminary estimates of the pharmacokinetics of olaparib in children and adolescents with relapsed or refractory cancer.


I. To explore approaches to profiling changes in tumor genomics over time through the evaluation of circulating tumor DNA.


Patients receive olaparib orally (PO) twice daily (BID) on days 1-28. Cycles repeat every 28 days for 2 years in the absence of disease progression or unacceptable toxicity.

Clinical Study Identifier: NCT03233204

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Cleveland Clinic Foundation

Cleveland, OH United States
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Kaiser Permanente-Oakland

Oakland, CA United States
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Ochsner Medical Center Jefferson

New Orleans, LA United States
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Sinai Hospital of Baltimore

Baltimore, MD United States
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Children's Hospital of Alabama

Birmingham, AL United States
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Children's Hospital Los Angeles

Los Angeles, CA United States
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Blank Children's Hospital

Des Moines, IA United States
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Norton Children's Hospital

Louisville, KY United States
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Children's Hospital New Orleans

New Orleans, LA United States
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C S Mott Children's Hospital

Ann Arbor, MI United States
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Geisinger Medical Center

Danville, PA United States
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Cook Children's Medical Center

Fort Worth, TX United States
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Primary Children's Hospital

Salt Lake City, UT United States
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M D Anderson Cancer Center

Houston, TX United States
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AdventHealth Orlando

Orlando, FL United States
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Mission Hospital

Asheville, NC United States
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Bronson Methodist Hospital

Kalamazoo, MI United States
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Recruitment Status: Open

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