Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder

  • STATUS
    Recruiting
  • End date
    Dec 1, 2024
  • participants needed
    120
  • sponsor
    Brigham and Women's Hospital
Updated on 12 July 2021
depression
bipolar disorder
mania
depressive episode
suicidal
lithium
fluoxetine

Summary

Lithium is highly effective in the treatment of bipolar disorder. This study aims to investigate, for the first time, the impact of lithium monotherapy on the structural and functional connectivity of the brain using MRI imaging.

Description

The premise of this proposal is that the clinical efficacy of lithium in bipolar disorder, and its complex effects on multiple brain physiological functions, may be best deciphered using a network properties-metric approach. This approach is critical because it provides insight into the function of brain networks (e.g., resilience to disruption, central hubs), which is likely to be more closely linked to behavioral outcomes. Furthermore, we will conduct an exploratory investigation of the in vivo molecular effects of lithium by measuring peripheral gene expression. To bring these together, we will also explore whether connectome changes serve as mediator between molecular changes (i.e., gene expression) induced by lithium treatment and behavioral changes (e.g., depression, mood stability, suicidality).

Details
Condition Endogenous depression, Depression, Bipolar Disorder, Depression (Major/Severe), Depression (Adolescent), Depression (Pediatric), Depression (Adult and Geriatric), Depression (Treatment-Resistant), Major Depressive Episode, Depressed, Bipolar Disorders (Pediatric), Manic Disorders, Bipolar I Depression, Bipolar II Depression, bipolar depression, depressive disorder, depression, bipolar, depressed mood, miserable, depressive disorders, major depressive disorder, single episode
Treatment Lithium
Clinical Study IdentifierNCT03336918
SponsorBrigham and Women's Hospital
Last Modified on12 July 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

ages 18-60 years and ability to give voluntary informed consent
no history of psychiatric illness or substance abuse or dependence
no significant family history of psychiatric or neurological illness in first degree relative
not currently taking any prescription or centrally acting medications
no use of alcohol in the past 1 week
and no serious medical or neurological illness

Exclusion Criteria

under 18 years of age
pregnant or breast-feeding
metallic implants or other contraindication to MRI
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