Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder
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- STATUS
- Recruiting
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- End date
- Dec 1, 2024
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- participants needed
- 120
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- sponsor
- Brigham and Women's Hospital
Summary
Lithium is highly effective in the treatment of bipolar disorder. This study aims to investigate, for the first time, the impact of lithium monotherapy on the structural and functional connectivity of the brain using MRI imaging.
Description
The premise of this proposal is that the clinical efficacy of lithium in bipolar disorder, and its complex effects on multiple brain physiological functions, may be best deciphered using a network properties-metric approach. This approach is critical because it provides insight into the function of brain networks (e.g., resilience to disruption, central hubs), which is likely to be more closely linked to behavioral outcomes. Furthermore, we will conduct an exploratory investigation of the in vivo molecular effects of lithium by measuring peripheral gene expression. To bring these together, we will also explore whether connectome changes serve as mediator between molecular changes (i.e., gene expression) induced by lithium treatment and behavioral changes (e.g., depression, mood stability, suicidality).
Details
| Condition | Bipolar I Depression, Bipolar Disorders (Pediatric), depressive disorder, major depressive disorder, single episode, Depression (Major/Severe), Major Depressive Episode, Bipolar II Depression, Depression (Adolescent), Depressed, depression, bipolar, Depression (Treatment-Resistant), Depression (Adult and Geriatric), depressive disorders, Depression, bipolar depression, depressed mood, Bipolar Disorder, miserable, Depression (Pediatric), Endogenous depression, Manic Disorders |
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| Treatment | Lithium |
| Clinical Study Identifier | NCT03336918 |
| Sponsor | Brigham and Women's Hospital |
| Last Modified on | 12 July 2021 |
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