Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder

  • End date
    Dec 1, 2024
  • participants needed
  • sponsor
    Brigham and Women's Hospital
Updated on 12 July 2021
bipolar disorder
depressive episode


Lithium is highly effective in the treatment of bipolar disorder. This study aims to investigate, for the first time, the impact of lithium monotherapy on the structural and functional connectivity of the brain using MRI imaging.


The premise of this proposal is that the clinical efficacy of lithium in bipolar disorder, and its complex effects on multiple brain physiological functions, may be best deciphered using a network properties-metric approach. This approach is critical because it provides insight into the function of brain networks (e.g., resilience to disruption, central hubs), which is likely to be more closely linked to behavioral outcomes. Furthermore, we will conduct an exploratory investigation of the in vivo molecular effects of lithium by measuring peripheral gene expression. To bring these together, we will also explore whether connectome changes serve as mediator between molecular changes (i.e., gene expression) induced by lithium treatment and behavioral changes (e.g., depression, mood stability, suicidality).

Condition Bipolar I Depression, Bipolar Disorders (Pediatric), depressive disorder, major depressive disorder, single episode, Depression (Major/Severe), Major Depressive Episode, Bipolar II Depression, Depression (Adolescent), Depressed, depression, bipolar, Depression (Treatment-Resistant), Depression (Adult and Geriatric), depressive disorders, Depression, bipolar depression, depressed mood, Bipolar Disorder, miserable, Depression (Pediatric), Endogenous depression, Manic Disorders
Treatment Lithium
Clinical Study IdentifierNCT03336918
SponsorBrigham and Women's Hospital
Last Modified on12 July 2021


Yes No Not Sure

Inclusion Criteria

ages 18-60 years and ability to give voluntary informed consent
no history of psychiatric illness or substance abuse or dependence
no significant family history of psychiatric or neurological illness in first degree relative
not currently taking any prescription or centrally acting medications
no use of alcohol in the past 1 week
and no serious medical or neurological illness

Exclusion Criteria

under 18 years of age
pregnant or breast-feeding
metallic implants or other contraindication to MRI
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note