Last updated on March 2019

Adapted Cognitive Behavioral Treatment for Depression in Patients With Moderate to Severe Traumatic Brain Injury

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Endogenous depression | Brain Injury | Major depression
  • Age: Between 18 - 50 Years
  • Gender: Male or Female

Inclusion Criteria:

  1. Adults aged 18 to 50, inclusive
  2. English language proficiency
  3. Ability to provide written, informed consent; OR consent provided by legally authorized representative with assent from subject
  4. Ability to see and hear (hearing or visual loss cannot impair ADLs or in-room conversation)
  5. Ability to attend in-person, outpatient sessions
  6. Having been hospitalized for moderate to severe TBI that occurred 6 months to 5 years prior to study entry
  7. Meeting ANY ONE of the following severity criteria, as documented in electronic medical record (EPIC) or available outside records:
  8. GCS 3-12 with GCS motor score 5 within 4 hours after injury
  9. GCS 3-12 with GCS motor score =6 within 4 hours after injury AND documented intracranial abnormalities on imaging
  10. GCS 13-15 within 4 hours after injury AND documented intracranial abnormalities on imaging
  11. Loss of consciousness (LOC) > 30 min.
  12. Post-traumatic amnesia (PTA) > 24 hours
  13. Out of PTA at the time of enrollment (GOAT>75)
  14. Current Major Depressive Episode as assessed by the MINI
  15. If taking medication for depression, must have been on stable dose for 4 weeks prior to study entry and no changes during the study.

Exclusion Criteria:

  1. Uncontrolled medical illness
  2. Behavioral dyscontrol, defined as the presence of verbally or physically aggressive behavior in the past month, as evidenced in medical records, pre-screening interviews, or observed by any study staff
  3. Meets criteria for PTSD, substance abuse or dependence within the past six months
  4. Has bipolar disorder, a primary psychotic disorder or current psychotic symptoms, or acute suicidality or homicidality
  5. Currently receiving regular ( 2 times/ mo.) psychosocial treatment for depression
  6. Has participated in CBT for depression within the past 6 months

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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