Genetic Basis of Melanocytic Nevi

  • End date
    Jan 26, 2025
  • participants needed
  • sponsor
    University of California, Davis
Updated on 26 November 2021


The objective of this protocol is to further elucidate the genetic mutations that drive melanocytic nevi (benign melanocytic neoplasms, moles). This will be performed by whole genome, whole exome, or targeted sequencing of de-identified specimens.

Herein, the investigators plan to isolate DNA from de-identified skin biopsy specimens and blood samples:

  1. From melanocytic nevi collected by skin biopsy (a shave or punch biopsy). A part of the tissue will be submitted for routine diagnostic dermatopathology and investigational histomorphologic and immunohistochemical analysis.
  2. From corresponding normal tissue (blood). DNA isolated from blood will be used as a normal control when analyzing sequencing data to identify somatic mutations in lesional tissue.

Condition Pigmented nevus
Treatment Collecting Nevi
Clinical Study IdentifierNCT03054584
SponsorUniversity of California, Davis
Last Modified on26 November 2021


Yes No Not Sure

Inclusion Criteria

Male or female subjects that are 18 years or older
Subjects with melanocytic nevi\

Exclusion Criteria

Patients less than 18 years of age
Patients without melanocytic nevi
Patients with a bleeding disorder or are taking anticoagulation medication
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