Intensity-Modulated Stereotactic Radiation Therapy in Treating Patients With Grade II-IV Glioma
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- STATUS
- Recruiting
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- End date
- Jan 1, 2024
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- participants needed
- 125
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- sponsor
- Sidney Kimmel Cancer Center at Thomas Jefferson University
Summary
This phase II trial studies how well intensity-modulated stereotactic radiation therapy works in treating patients with grade II-IV glioma. Stereotactic radiosurgery is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor and may cause less damage to normal tissue.
Description
PRIMARY OBJECTIVES:
I. To determine the effect of intensity-modulated (IM)-stereotactic radiotherapy (SRT) on the incidence of wound infection (requiring oral/intravenous [IV] antibiotics or surgery), or wound dehiscence.
SECONDARY OBJECTIVES:
I. To determine the effect of IM-SRT on the incidence of titanium implants as palpable cranial defects due to scalp thinning.
II. To determine the effect of IM-SRT on the incidence of hair loss and recovery rate.
III. To determine the effect on quality of life (QoL) using European Quality of Life Five Dimension Five Level Scale Questionnaire (EQ-5D-5L).
TERTIARY OBJECTIVES:
I. To determine if treatment of Intensity-modulated stereotactic radiotherapy (IM-SRT) in patients with newly diagnosed grade II-IV gliomas can decrease the loss of scalp thickness in the coronal plane in T-1W magnetic resonance (MR) images.
Details
| Condition | Glioblastoma, WHO Grade II Glioma, WHO Grade III Glioma |
|---|---|
| Treatment | intensity-modulated radiation therapy, Quality-of-Life |
| Clinical Study Identifier | NCT03251027 |
| Sponsor | Sidney Kimmel Cancer Center at Thomas Jefferson University |
| Last Modified on | 31 January 2022 |
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