Last updated on June 2018

QUALIOR Feasibility and Efficacy of a Supervised Home-based Standard Physical Exercise Program

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Patients Receiving Oraltargeted Therapy for Metastatic Cancer | Home Based Standardised Adapted Physical Activity Programme
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  1. Patient's 18 years old.
  2. Patient treated for a metastatic solid tumour within the following 4 cohorts: breast cancer, kidney cancer, lung cancer, and other tumours treated with oral targeted therapies (including melanomas, sarcomas, hepatic sarcomas, and colon cancers).
  3. Patients starting first-line oral targeted therapy, with market authorisation. The targeted therapy may be associated with hormonal therapy.
  4. Patients may have been treated with immunotherapy.
  5. Patients may have received chemotherapy (2 lines) for their metastatic disease.
  6. Life expectancy of 3 months.
  7. ECOG performance status 2.
  8. Patients able to comply with the constraints of the standardised supervised physical activity (SSPA) protocol.
  9. Pain under control (VAS 3; 0-10 scale).
  10. Haemoglobin level 9 g/dL.
  11. Patient must have signed the informed consent form before any study-related procedures.
  12. Patients must have public health insurance coverage.

Exclusion Criteria:

  1. Patient receiving an injectable targeted therapy.
  2. Patient previously treated with an oral targeted therapy (previous cytokine treatment allowed).
  3. Patient to be treated with chemotherapy associated with the oral targeted therapy (hormonal therapy is allowed).
  4. Patient with known risk of fracture, symptomatic cardiac insufficiency (NYHA-3), respiratory insufficiency (grade 3), intense pain not controlled with analgesic treatment, and/or neuropathy (grade 3).
  5. Patients with a history of cancer in the last 5 years (except basal cell carcinoma adequately treated and in situ cervical cancer treated and cured).
  6. Patient treated with corticotherapy (1 month) before randomisation at a dose 1 mg/kg.
  7. Bone metastases with risk of fractures.
  8. Geographical, sociological, or psychological reasons that could potentially hampering compliance with the study protocol and follow-up schedule.
  9. Patients with a history of non-compliance to medical treatment, reluctance or incapable to conform to the study protocol.
  10. Persons deprived of liberty or under guardianship. -

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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