Last updated on February 2018

EDIT Management Feasibility Trial

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: malignant pleural effusion
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Clinically confident diagnosis of malignant pleural effusion, defined as any of the
    1. Pleural effusion with histocytologically proven pleural malignancy OR
    2. Pleural effusion in the context of histocytologically proven malignancy elsewhere, without a clear alternative cause for fluid OR
    3. Pleural effusion with typical features of malignancy with pleural involvement on cross-sectional imaging (CT/MRI)
  • Degree of breathlessness for which therapeutic pleural intervention would be offered
  • Age >18 years
  • Expected survival > 3 months
  • Written Informed Consent

Exclusion Criteria:

  • Females who are pregnant or lactating
  • Clinical suspicion of non-expansile lung for which talc pleurodesis would not be offered
  • Patient preference for 1st-line indwelling pleural catheter (IPC) insertion
  • Previous ipsilateral failed talc pleurodesis
  • Estimated pleural fluid volume 1 litre, as defined by thoracic ultrasound
  • Any contraindication to chest drain or IPC insertion, including:

Irreversible coagulopathy Inaccessible pleural collection, including lack of suitable IPC tunnel site

  • Any contraindication to MRI scanning, including:

Claustrophobia Cardiac pacemaker Ferrous metal implants or retained ferrous metal foreign body Previously documented reaction to Gadolinium-containing intravenous contrast agent Significant renal impairment (eGFR<30 ml/min)

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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