Last updated on May 2019

Is Cognitive Training Neuroprotective in Early Psychosis?


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: healthy | Psychosis
  • Age: Between 16 - 35 Years
  • Gender: Male or Female

First Episode Psychosis (FEP) Participants

Inclusion Criteria:

  • Enrolled in the Mini-COTES randomized controlled trial examining cognitive training in First Episode Psychosis (NCT03079024)
  • Clinical diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, major depressive disorder with psychotic features, bipolar disorder with psychotic features, psychosis disorder not otherwise specified, or unspecified schizophrenia spectrum disorder, and started receiving treatment services at a First Episode Psychosis Program within the last two years
  • Good general physical health
  • Age between 16 and 35 (inclusive)
  • Fluent in written and spoken English
  • No neurological disorder (diagnosis of Autism Spectrum Disorder is allowed)
  • Achieved clinical stability, defined as outpatient status for at least one month prior to study participation, stable doses of psychiatric medications for at least one month prior to study participation
  • Women who are pregnant or breastfeeding may participate in this study

Healthy Controls (HC) Participants

Inclusion Criteria:

  • Age between 16 and 35 (inclusive)
  • Fluent in English
  • Good general physical health
  • No neurological disorder
  • No current or past diagnosis of a psychotic disorder, mood disorder, or anxiety disorder

All Participants

Exclusion Criteria:

  • Unable to provide informed consent (or assent if under 18)
  • Parents do not provide consent for participants under 18
  • Clinically significant substance abuse that is impeding the subject's ability to participate fully during recruitment, assessment, or training (is unable to remain sober for assessments).
  • Cannot pass the CMRR safety screen for receiving an MRI
  • Participant does not comply with study procedures. Exclusion is determined at PI discretion.

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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