Measurement of Renal Functional Reserve

  • End date
    Jun 1, 2022
  • participants needed
  • sponsor
    Brigham and Women's Hospital
Updated on 22 January 2021
glomerular filtration rate


Single arm physiological study to measure renal functional reserve as a biomarker of kidney function and health


The investigators will measure glomerular filtration rate using urinary clearance of cold iothalamate before and after an oral protein load in patients with chronic kidney disease and healthy volunteers.

Condition Nephropathy, Kidney Disease (Pediatric), Kidney Disease, renal disease, kidney diseases, kidney disorders, nephrologic disease, kidney disorder, disease, kidney
Treatment Ingestion of protein
Clinical Study IdentifierNCT03190070
SponsorBrigham and Women's Hospital
Last Modified on22 January 2021


Yes No Not Sure

Inclusion Criteria

Is your age greater than or equal to 18 yrs?
Gender: Male or Female
Do you have Nephropathy?
Do you have any of these conditions: disease, kidney or Nephropathy or kidney disorder or kidney diseases or renal disease or Kidney Disease or nephrologic disease or Kidney Disease (Pedi...?
Age 18
Estimated GFR >30 mL/min/1.73m2

Exclusion Criteria

Allergy to iothalamate, shellfish or iodine
Use of metformin or amiodarone
Inability to maintain a stable regimen of medications which affect GFR for > one week prior to participation (e.g. non-steroidal anti-inflammatory drugs, angiotensin converting enzyme inhibitors, angiotensin receptor blockers)
Use of medications which directly affect elimination of creatinine (e.g. cimetidine and trimethoprim)
Acute exacerbation of asthma or chronic obstructive pulmonary disease within 3 months requiring hospitalization or oral steroid therapy
Inadequate intravenous access
Severe anemia (Hct <21%)
Acute kidney injury (rise in creatinine to 1.5 times the previous baseline or by 0.3 mg/dL on most recent labs prior to enrollment)
History of contrast-induced nephropathy
Sickle cell disease
Urinary retention or incontinence
Status post organ transplant
Pregnancy or active breast feeding
Cognitive impairment with inability to give consent
Institutionalized status
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