Last updated on October 2018

A Study of RO7198457 (Personalized Cancer Vaccine [PCV]) as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Tumors


Brief description of study

This is a Phase 1a/1b, open-label, multicenter, global, dose-escalation study designed to evaluate the safety, tolerability, immune response, and pharmacokinetics of RO7198457 as a single agent and in combination with atezolizumab (MPDL3280A, an engineered anti-programmed death-ligand 1 [anti-PD-L1] antibody).

Clinical Study Identifier: NCT03289962

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HonorHealth Research Institute - Pima Center
Scottsdale, AZ United States
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The Angeles Clinic
Los Angeles, CA United States
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UCSF Comprehensive Cancer Ctr
San Francisco, CA United States
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Stanford Cancer Center
Stanford, CA United States
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University of Colorado
Aurora, CO United States
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Yale University Cancer Center, Smilow Cancer Hospital; Medical Oncology
New Haven, CT United States
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Georgetown University
Washington, WA United States
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Massachusetts General Hospital.
Boston, MA United States
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Beth Israel Deaconess Medical Center
Boston, MA United States
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Dana Farber Can Ins
Boston, MA United States
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Comprehensive Cancer Centers of Nevada (CCCN) - Central Valley
Las Vegas, NV United States
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Columbia University Medical Center; Clinical Research Management Office
New York, NY United States
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Memorial Sloan Kettering Cancer Center
New York, NY United States
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University of Oklahoma Health Sciences Center
Oklahoma City, OK United States
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Providence Oncology and Hematology Care Eastside
Portland, OR United States
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University of Pittsburgh Medical Center
Pittsburgh, PA United States
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Sarah Cannon Res Inst; TN Onc
Nashville, TN United States
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Seattle Cancer Care Alliance
Seattle, WA United States
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Sint Augustinus Wilrijk
Wilrijk, Belgium
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The Ottawa Hospital Cancer Centre; Oncology
Ottawa, ON Canada
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Princess Margaret Cancer Center; Department of Radiation Oncology
Toronto, ON Canada
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Universit tsklinikum Essen; Innere Klinik und Poliklinik f r Tumorforschung
Essen, Germany
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Nationales Centrum f r Tumorerkrankungen Heidelberg (NCT); Thoraxklinik Heidelberg
Heidelberg, Germany
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Fachklinik f r Lungenerkrankungen
Immenhausen, Germany
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Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz
Mainz, Germany
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Antoni van Leeuwenhoek Ziekenhuis
Amsterdam, Netherlands
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Universitair Medisch Centrum Utrecht
Utrecht, Netherlands
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Clinica Universitaria de Navarra; Servicio de oncolog a
Pamplona, Spain
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Hospital Univ Vall d'Hebron; Servicio de Oncologia
Barcelona, Spain
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Akademiska sjukhuset, Onkologkliniken
Uppsala, Sweden
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Barts & London School of Med; Medical Oncology
London, United Kingdom
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Southampton General Hospital; Medical Oncology
Southampton, United Kingdom
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The Royal Marsden Hospital
Sutton, United Kingdom
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Karolinska Hospital; Oncology - Radiumhemmet
Stockholm, Sweden
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LungenClinic Gro hansdorf
Großhansdorf, Germany
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Recruitment Status: Open


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